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31 May 2018 Photo Anja Aucamp
Microbiology department receives Research Chair in Pathogenic Yeasts Prof Carlien Pohl-Albertyn
Prof Carlien Pohl-Albertyn, Professor in the Department of Microbial, Biochemical and Food Biotechnology


The National Research Foundation (NRF) recently approved a fifth research chair for the University of the Free State (UFS), the Research Chair in Pathogenic Yeasts. Prof Carlien Pohl-Albertyn from the Department of Microbial, Biochemical and Food Biotechnology, will be chairing this research chair. 

Activities of the Research Chair in Pathogenic Yeasts builds on existing research strengths and will contribute towards understanding pathobiology of medically significant pathogenic yeasts belonging to the genera Candida and Cryptococcus. 

According to Prof Pohl-Albertyn, the research group, established in 2014, is the only one in South African focusing on understanding the role of bioactive lipids in host-pathogen interaction as well as in the search for novel drug targets. The group brought together three principal investigators, Prof Pohl-Albertyn, Prof Koos Albertyn and Dr Olihile Sebolai, with knowledge regarding various virulence factors (including immunomodulatory metabolites) produced by the Candida and Cryptococcus as well as molecular biology of yeasts. Besides the three principal investigators, the group also includes five PhD students, nine MSc students, four BSc honours students as well as two postdoctoral fellows. 

Current projects of the group include the production of immunomodulatory compounds by the yeasts, finding novel targets for antifungal drugs and the interaction between the yeasts and different hosts using a variety of infection models. In addition, the interaction between pathogenic yeasts and other co-infecting pathogens is also being investigated. 

Why research on fungal infections?
“As a result of presently used treatments for diseases and HIV/Aids, and the advances in medical interventions, many diseases no longer pose a threat to humans and life expectancy is prolonged. However, this has also caused an increase in various opportunistic infections, and most of all, fungal infections.

“With an increase in the number of individuals sensitive to invasive fungal infections, yeasts have begun to be reported more frequently as pathogens (yeasts that can cause disease). Infections by pathogenic yeasts affect a wide variety of patients. Although most of them are immunosuppressed (including HIV positive) other underlying conditions may predispose people to such infections. These include extremes of age (premature infants and the elderly), diabetes, cancer and cystic fibroses. In addition, patients hospitalised in intensive care units, as well as patients undergoing major abdominal or thoracic surgery are at high risk of invasive candidiasis. Similarly, HIV/Aids, liver cirrhosis and immunosuppressive therapy are known risk factors for invasive cryptococcosis,” said Prof Pohl-Albertyn.

According to her an important hurdle in the treatment of invasive yeast infection is the emergence of drug resistance in these pathogens. Therefore, research into pathobiology, including new drug targets, as well as novel treatment options, is a necessity. 

In line with the UFS research strategy
The NRF call for research chairs, specifically aimed at female researchers at universities that currently have fewer than 15 research chairs, came out in May 2017.

The university considers the current SARChi Chairs and the possibility of future chairs as an integral and strategic initiative to increase its national and international standing through excellent academic and research leadership. A Research Chair in Pathogenic Yeasts is therefore an invaluable addition to the UFS Research Strategy. 

The Research Chair is for five years, and is renewable for three terms.

Microbiology from University of the Free State on Vimeo.

News Archive

Ferial Haffajee among graduates at Summer Graduation
2016-12-02

Description: Summer graduation Tags: Summer graduation 

A total of 124 master’s, 37 doctoral degrees, and
464 undergraduate degrees are conferred on students from
all seven faculties during the Summer Graduations.
Photo: Johan Roux

Graduation is a time to celebrate and to reap the fruits of hard work. The journalist Ferial Haffajee (Humanities) will be among the 124 master’s and 37 doctoral students receiving their qualifications in all seven faculties at the Summer Graduation of the University of the Free State (UFS). At the ceremonies on 8 December 2016 in the Callie Human Centre on the Bloemfontein Campus, the university will also confer 264 Education qualifications to students from its South Campus, as well as 200 undergraduate degrees in the Faculty of Health Sciences.

Haffajee joins likes of Tutu and others

Haffajee, a renowned newspaper editor whose expertise has made her one of the most prominent journalists in South Africa, will receive an honorary doctorate at the morning ceremony. Until recently she was the editor-in-chief of City Press newspaper. She joins the likes of Desmond Tutu, and others who have received honorary doctorates at the UFS.

Earlier this year, four distinguished individuals also received honorary doctorates from the university. They were Max du Preez, Trevor Manuel, Prof Joel Samoff, and Dr Reuel Jethro Khoza. The Summer Graduation once again promises to deliver the cream of academic excellence.

Dr Rakometsi to address UFS graduates

The guest speaker at both ceremonies is Dr Mafu Rakometsi, Chief Executive Officer of Umalusi. Dr Rakometsi also serves on the board of the Council of Higher Education. He is deeply committed to see the South African education system function at an optimum level in order to give all children equal educational opportunities.

Master’s and Doctoral degrees: All faculties

Date: 8 December 2016
Place: Callie Human Centre, Bloemfontein Campus
Time: 09:00

Education qualifications – South Campus, as well as undergraduate degrees in the Faculty of Health Sciences
Date: 8 December 2016
Place: Callie Human Centre, Bloemfontein Campus
Time: 14:30

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