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31 May 2018 Photo Anja Aucamp
Microbiology department receives Research Chair in Pathogenic Yeasts Prof Carlien Pohl-Albertyn
Prof Carlien Pohl-Albertyn, Professor in the Department of Microbial, Biochemical and Food Biotechnology


The National Research Foundation (NRF) recently approved a fifth research chair for the University of the Free State (UFS), the Research Chair in Pathogenic Yeasts. Prof Carlien Pohl-Albertyn from the Department of Microbial, Biochemical and Food Biotechnology, will be chairing this research chair. 

Activities of the Research Chair in Pathogenic Yeasts builds on existing research strengths and will contribute towards understanding pathobiology of medically significant pathogenic yeasts belonging to the genera Candida and Cryptococcus. 

According to Prof Pohl-Albertyn, the research group, established in 2014, is the only one in South African focusing on understanding the role of bioactive lipids in host-pathogen interaction as well as in the search for novel drug targets. The group brought together three principal investigators, Prof Pohl-Albertyn, Prof Koos Albertyn and Dr Olihile Sebolai, with knowledge regarding various virulence factors (including immunomodulatory metabolites) produced by the Candida and Cryptococcus as well as molecular biology of yeasts. Besides the three principal investigators, the group also includes five PhD students, nine MSc students, four BSc honours students as well as two postdoctoral fellows. 

Current projects of the group include the production of immunomodulatory compounds by the yeasts, finding novel targets for antifungal drugs and the interaction between the yeasts and different hosts using a variety of infection models. In addition, the interaction between pathogenic yeasts and other co-infecting pathogens is also being investigated. 

Why research on fungal infections?
“As a result of presently used treatments for diseases and HIV/Aids, and the advances in medical interventions, many diseases no longer pose a threat to humans and life expectancy is prolonged. However, this has also caused an increase in various opportunistic infections, and most of all, fungal infections.

“With an increase in the number of individuals sensitive to invasive fungal infections, yeasts have begun to be reported more frequently as pathogens (yeasts that can cause disease). Infections by pathogenic yeasts affect a wide variety of patients. Although most of them are immunosuppressed (including HIV positive) other underlying conditions may predispose people to such infections. These include extremes of age (premature infants and the elderly), diabetes, cancer and cystic fibroses. In addition, patients hospitalised in intensive care units, as well as patients undergoing major abdominal or thoracic surgery are at high risk of invasive candidiasis. Similarly, HIV/Aids, liver cirrhosis and immunosuppressive therapy are known risk factors for invasive cryptococcosis,” said Prof Pohl-Albertyn.

According to her an important hurdle in the treatment of invasive yeast infection is the emergence of drug resistance in these pathogens. Therefore, research into pathobiology, including new drug targets, as well as novel treatment options, is a necessity. 

In line with the UFS research strategy
The NRF call for research chairs, specifically aimed at female researchers at universities that currently have fewer than 15 research chairs, came out in May 2017.

The university considers the current SARChi Chairs and the possibility of future chairs as an integral and strategic initiative to increase its national and international standing through excellent academic and research leadership. A Research Chair in Pathogenic Yeasts is therefore an invaluable addition to the UFS Research Strategy. 

The Research Chair is for five years, and is renewable for three terms.

Microbiology from University of the Free State on Vimeo.

News Archive

PSP allows Dr Thom Wium to develop as an academic
2016-12-26

Description: Matildie PSP Tags: Matildie PSP 

For Dr Matildie Thom Wium, the
rewarding part of teaching is “the
moments of synergy with a group of
students” and when she senses that she
could, for instance, help them to better
understand a music selection.
Photo: Sonia Small

Being part of the Vice-Chancellor’s Prestige Scholars Programme (PSP) has opened doors for Dr Matildie Thom Wium. She is able to better plan her research, and the overseas trips she has to undertake for this helps to develop her skills.

The senior lecturer in the Odeion School of Music (OSM) at the University of the Free State (UFS) says these are some of the advantages the PSP holds for her.

She attended two international conferences this year – in London in January, and in New York in August. Furthermore, she is working on musical analysis with Prof Timothy Jackson at the University of North Texas, US from 12 September 2016 to 31 December 2016. Prof Jackson is a research professor and was one of her PhD promoters.

Conferences contribute to her vision
“I think the PSP is a fantastic initiative,” says Dr Thom Wium, whose husband Daniël Wium is a lecturer in Astrophysics at the UFS. She says the reseach support from the PSP is amazing. “In addition, the writing retreats offered by the PSP help to set time aside during the busy semester to work on articles.”

“I think the PSP is a fantastic initiative.”

The conference in London was on operatic practice in the 19th century. In the US, Dr Thom Wium, who has been working at the UFS since 2007, also participated in a panel discussion on this topic. “It means a lot for my vision as an academic to participate in conferences where I have the opportunity to meet and exchange thoughts with the people whose work I read and cite.”

Involvement in SA equally important

However, she believes that it is equally important to stay involved locally. At the conference of the South African Society for Research in Music, which was hosted by the OSM from 25 to 27 August 2016, she presented a paper on composer Arnold van Wyk and performed a song cycle by him. She did research on Van Wyk for her PhD.

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