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28 November 2018 | Story Moeketsi Mogotsi | Photo Moeketsi Mogotsi
Nettah read more
Limpopo-born Law student Anet Matakala’s giant leap of faith by entering the Shoprite Hustler of the Month competition.

Anet Matakala is a Law student who recently had a brilliant, sensational experience when she received recognition as an up-and-coming entrepreneur by Shoprite through their Hustler of the Month Entrepreneur competition.

Matakala is the owner of Nettah Organics, a personal healthcare-product company which uses food-based products to handcraft products for the skin, hair, and body. These products include healthy foodstuffs such as avocados, coffee, green tea, and cinnamon.

She says due to the lack of organic products on the market, she initially made products only for herself. However, in 2017, friends and family started showing interest and she decided to distribute her products among them.

Matakala, who hails from Limpopo, says she formally registered the company in April 2018, while continuing with the same business model.

Making bold moves

The 24-year-old says a friend encouraged her to enter the Shoprite competition after seeing a promo run on social media.

She says signing up for the competition was a leap of faith which yielded results that she hardly expected.

“I was actually playing when I entered. They only responded to me after two months, and at first, I didn’t know that I won; I thought I was just a finalist. A week after that, they told me that they have arranged a photographer to take photos of me and my products. When I asked what it’s for, they told me I had won,” she says.

Her prize as the Shoprite Hustler of October includes a cash prize, sponsored radio marketing, social-media coverage and a crowdfund page for Nettah Organics.

“It [the competition] increased my sales. The competition actually helped me, because a lot of people became interested in my stuff and they started enquiring about them," she adds.

Looking forward, Matakala says she would like to see her products on shelves in retail stores.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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