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26 October 2018
Dr Annamarie van Jaarsveld believes occupational therapy is important
Dr Annamarie van Jaarsveld believes occupational therapy is important for personal well-being.

On 27 October the profession of occupational therapy is promoted and celebrated internationally. The theme for this year is “Celebrating our global community.” Due to the theme of this year occupational therapists form all over the globe will be able to join in the World Federation for Occupational Therapy Virtual Exchange webinars.
 
Occupational therapy promotes health and well-being through occupation. The overarching goal of occupational therapy is to enable people to participate in the activities of everyday life that is meaningful to them. Occupational therapists work with people and communities in an effort to enable people of all ages to live life to its fullest by helping them maintain and/or promote health, and prevent (or live better with) injury, illness, or disability. 

Common occupational therapy interventions include helping children with disabilities to participate fully in school and social situations, helping people recovering from injury to regain skills, and providing supports for older adults experiencing physical and cognitive changes. Occupational and social justice along with occupational deprivation are core within the profession as it relates to oppression or restrictions to participation in occupation impacting on well-being and quality of life. 

Taking the lead in Sensory Integration research

Dr Annamarie van Jaarsveld is a lecturer in the Department of Occupational Therapy, and she is at the forefront of research in sensory integration, a specialist field within occupational therapy. Apart from completing her PhD on the curriculum design of a South African professional master’s degree qualification in sensory integration, she is also heading the South African leg of a large international study in collaboration with sensory integration experts all over the world.

Dr Van Jaarsveld explains: “The Evaluation of Ayres Sensory Integration (EASI) is a new test which aims to be a first of its kind in the field of sensory integration and occupational therapy. It will be inexpensive, electronically accessible and practical, and standardised on an international population which includes a South African sample. This will make the test accessible and useful for therapists in South Africa to be able to assess sensory integration related function of all South African children in a valid and reliable manner.” 

In addition to being the South African lead on the international EASI standardisation study, Annamarie was selected as the chairperson of the Board of Council Meetings of the International Council for Education in Ayres Sensory Integration (ICEASI). She is also the International Liaison on the board of the South African Institute for Sensory Integration. 

Annamarie’s passion for sensory integration and the application of a highly researched and specialised subfield where the expertise and guidance are provided by a first-world country is not only evident in her research, but also in various community projects that she is involved in. One such a project, Back to Urth Playgrounds, aims to make sensory integration relevant to the needs of South African children and their families struggling with sensory integration issues within the realities of diverse contexts. Through the designing of sustainable playgrounds based on sensory integration theory, building the playgrounds in collaboration with the community and other stakeholders, and equipping educators and caregivers with knowledge on how to encourage children to use the playgrounds, Annamarie has contributed to making the potential of sensory integration-based intervention accessible to the most under-resourced of areas. 

With the 27th of October being International Occupational Therapy Day, Annamarie says: “Sensory integration is not only the best researched field within occupational therapy, providing more and more best practice evidence through rigorous research, it is also becoming more available to children and families from all walks of life – indeed exciting times ahead for this field of practice and it remains a privilege to be involved in it”.  

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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