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31 October 2018 Photo Charl Devenish
PhD students compete in three-minute thesis competition
The ten PhD students who participated in the Three-Minute-Thesis Competition.

Ten Doctor of Philosophy (PhD) students from five universities across the country were pitted against one another in the robust finals of the annual national Three-Minute Thesis (3MT) competition, held at the University of the Free State (UFS).

Postgraduate School Assistant Officer, Kamogelo Dithebe, said this is a research-communication competition developed by the University of Queensland, whereby PhD students are given three minutes to present a compelling oration on their thesis and its significance.

The competition challenges students to consolidate their ideas and research discoveries to be presented concisely to a non-specialist audience.

Developed in 2008, enthusiasm for the 3MT concept and its adoption in numerous universities has led to the development of an international competition. Students become eligible to participate in the national competition once they have participated in the competition at institutional level.
 
Dithebe stated that the institutional winner and the runner-up become eligible for representation at national level. Institutions that participated in the 2018 national competition were the University of KwaZulu-Natal, the University of Johannesburg, the University of Cape Town, Durban University of Technology, as well as the hosts, the University of the Free State.

Research on water-leakage problems comes out tops

The University of Cape Town’s Civil Engineering student, Rene Nsanzubuhoro, pipped all his counterparts to walk away with a R16 000 prize as well as a People’s Choice prize of R6 000 – this is where the audience were given ballots to vote for their choice. His topic was: Fighting leakage one pipe at a time

The core focus of his research was leakage in water-pipe systems. This is a major concern to water utilities for several reasons, including loss of a limited resource, pumping energy, revenue loss, and increased health risk as leaks are potential entry points for contaminants if a pressure drop occurs in the system. In the study, a novel device for assessing the condition of water-pipe systems was designed, constructed, and tested.

Research on clean water takes a second spot

The runner-up was a Chemical Engineering student from the University of Johannesburg, Oluwademilade Fayemiyo, who won a prize of R11 000. Her topic was: From wine to water: Searching within for clean water.

Two students from the University of the Free State, Trudie Strauss and Nokuthula Tlalajoe, represented the institution.

Strauss, who is a Mathematical Statistics student, talked about: Babelish Confusion: Finding statistical structure in the diversity of language.

Tlalajoe, a Health Professions Education student, presented the topic: Multiple transition for undergraduate first-year students in the MB CHB programme: Expectations, Experiences, and Emotions.

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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