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12 September 2018 Photo iFlaire
Architectural excellence celebrated at recent Sophia Gray lecture
Prof ‘Ora Joubert, a leading architect and academic, delivered the 30th Sophia Gray Memorial Lecture at the UFS.

A jolly kink, creative, aesthetically sensible, a dream house, welcoming, true colours, bright lights – these are some of the terms one can use to describe the work of Prof ‘Ora Joubert, leading architect, academic and former head of the UFS Department of Architecture.

A journey through time and space

She is also the 30th laureate to deliver the recent Sophia Gray Memorial Lecture on the Bloemfontein Campus of the University of the Free State (UFS). The lecture was titled: La Promenade Architecturale – A journey through time and space. “The title refers to the revelatory experience of an observer who wanders on a pathway in and through architectural spaces,” said Jan Ras, lecturer in the Department of Architecture and organiser of the event. 
“As the observer tours the architectural configuration, a sequence of composed images, themes and ordering systems are revealed. This gradually unfolds as the observer moves through the spaces,” Ras said.

The lecture, which coincided with an exhibition at the Oliewenhuis Art Museum, is a highlight of the South African architectural community and celebrates outstanding practitioners and academics in architecture.

Besides the numerous design awards she received as practitioner, Prof Joubert’s work has also received critical acclaim internationally in publications from Australia, to Russia and the UK. In 2001 she was cited as one of the most esteemed architects under the age of 40 and her work was included in the 2004 Phaidon Atlas of Contemporary Architecture. She is also a well-respected academic with 34 articles published in a variety of publications.

Recognising the intelligence and ingenuity of design

Prior to the lecture, the department also presented a mini-congress, introducing the new PhD with Design programme. This programme recognises the intelligence and ingenuity of design and is aimed at, among others, younger MArch graduates who wish to explore creative research. The department envisaged that the PhD study might be practice-based for architects who wish to document and research their own work and or design-led for candidates who wish to explore a new creative project. 

Forming part of this week filled with architectural creativity was a fundraising breakfast, with contributions going to the Sophia Gray Bursary Fund. The fund is part of a greater call to alumni and friends to be actively involved in the department’s continuous development and future endeavours towards imagination, care and excellence. 

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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