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26 April 2019 | Story Opinion article by Dr Chitja Twala | Photo Sonia Small
Dr Chitja Twala
Dr Chitja Twala is the Vice-Dean of the Faculty of the Humanities at the University of the Free State.

This opinion piece is to reflect on the sacrifices and roles played by the Twelve Disciples in the Liberation Struggle in honour of #Freedom Day.

To the majority of South Africans, the struggle for liberation centres around high-profiled political leaders such as Nelson Mandela, Walter Sisulu, Govan Mbeki, Robert Sobukwe, Steve Biko, and others. Less known is the experience of a generation of young men who left South Africa clandestinely to build the ANC and spread its liberation message in places abroad. These young men became known as the Twelve Disciples of Mandela. Like many other youngsters who became political activists elsewhere in the country, this group received its political conscientisation at school at the then Bantu High School (later known as Sehunelo High School).

This group of youngsters came from the Mangaung township in Bloemfontein, although it is not clear why they were referred to as the Twelve Disciples of Mandela. When they left Bloemfontein, they were destined to join MK in exile. The formation of MK was announced on 16 December 1961. At the same time, MK began a sabotage campaign against strategic installations throughout South Africa. In a leaflet issued on 16 December 1961, the MK high command made its political allegiance quite clear by stating: “Umkhonto we Sizwe will carry on the struggle for freedom and democracy by methods which are necessary to complement the actions of the established national liberation organisations. Umkhonto we Sizwe fully supports the national liberation movement and calls on members, jointly and individually, to place themselves under the overall political guidance of the movement”. During the initial stages of its formation, MK avoided openly mentioning the ANC for tactical reasons. MK sought to protect the leadership of the ANC from reprisals by the South African government, in particular those who had nothing to do with the decision to take the route of armed struggle.

It is clear from interviews conducted with the surviving members of this group that nobody knew exactly why they were called the Twelve Disciples, except that there was a plan conceived by Mandela, called the M-Plan, calling for the total restructuring of the ANC to enable it to operate underground should it get banned. However, although several authors such as Edward Feit, Karis and Carter, Nelson Mandela, and Bruno Mtolo and a number of court records provide information on the M-Plan, details are sketchy.

The group of young men from Bloemfontein were Billy ‘Marakas’ Mokhonoana (left the country earlier than the others and allegedly died in London); Selebano ‘Tlhaps’ Matlhape (left for Tanganyika and later studied in Yugoslavia and East Germany); Theodore ‘Max’ Motobi (left for Tanganyika and underwent military training in Cuba); Moses ‘Dups’ Modupe (left for Tanganyika and later studied Economics in Yugoslavia); Benjamin ‘Lee’ Leinaeng (left for Tanganyika and later studied journalism in East Germany); Joseph Shuping ‘Coaps’ Coapoge (left for Tanganyika and later attended Lincoln and Temple Universities in the US); Elias Pule Matjoa (worked in the Ministry of Communications in Tanzania and underwent military training in Cuba. He later studied dentistry there); Percy Mokonopi (received military training in Cuba and later served on the Helsinki World Peace Council); Mochubela ‘Wesi’ Seekoie (left for Tanganyika and underwent military training in Cuba. He later studied Chemistry in the USSR); Matthew Olehile ‘Beans’ Mokgele (left for Tanganyika and became a professional boxer in exile. Following an injury, he went to East Africa and joined the MK); Bethuel Setai (left for Tanganyika and later obtained a PhD in Economics from Colombia University. He taught at the University of California Santa Cruz, and Lincoln University in the USA) ; and Peter Swartz (was an active member of the ANC from the coloured community in Bloemfontein. He met with the group in Dar es Salaam, following his arrest on his way to Tanzania. He attended Kivukoni College and later went to the UK where he attended the London School of Economics. He went missing in London in 1965, never to be seen again).

In honour of many of these unsung heroes, the history of the Twelve Disciples needs to be told to reflect what one could refer to as a ‘bottom up’ kind of history. Without doubt, this kind of history will add value to the country’s historiography about the liberation struggle and demystify the one-sided narrative that the (Orange) Free State played little if no role at all in the struggle for liberation.



News Archive

Cardiology Unit involved in evaluation of drug for rare genetic disease
2013-01-04

Front from the left, are: Marinda Karsten (study coordinator and registered nurse),
Laumarie de Wet (clinical technologist), Charmaine Krahenbuhl (study coordinator and radiographer),
Lorinda de Meyer (administrator), Andonia Page (study coordinator and enrolled nurse);
back Dr Gideon Visagie (sub investigator), Dr Derick Aucamp (sub investigagtor),
Prof. Hennie Theron, (principal investigator) and Dr Wilhelm Herbst (sub investigator).
Photo: Supplied
09 January 2013


The Cardiology Research Unit at the University of the Free State (UFS) contributed largely to the evaluation of the drug Juxtapid (lomitapide), which was developed by the Aegerion pharmaceutical company and approved by the FDA (Federal Drug Administration). Together with countries such as die USA, Canada and Italy, the UFS’ Unit recruited and evaluated the most patients (5 of 29) for the study since 2008.  

The drug was evaluated in persons with so-called familial homozygous hypercholesterolemia (HoFH).  

Following its approval by the FDA, Juxtapid is now a new treatment option for patients suffering from HoFH. The drug operates in a unique way which brings about dramatic improvements in cholesterol counts.  

According to Prof. Hennie Theron, Associate Professor in the Department of Cardiology at the UFS and Head of the Cardiology Contract Research Unit, HoFH is a serious, rare genetic disease which affects the function of the receptor responsible for the removal of low-density lipoprotein cholesterol (LDL-C) (“bad” cholesterol) from the body. Damage to the LDL receptor function leads to extremely high levels of blood cholesterol. HoFH patients often develop premature and progressive atherosclerosis, which is a narrowing or blockage of the arteries.  

“HoFH is a genetically transmitted disease and the most severe form of hypercholesterolemia. Patients often need a coronary artery bypass or/and aortic valve replacement before the age of 20. Mortality is extremely high and death often occurs before the third decade of life. Existing conventional cholesterol-lowering medication is unsuccessful in achieving normal target cholesterol values in this group of patients.  

“The only modality for treatment is plasmapheresis (similar to dialysis in patients with renal failure). Even with this type of therapy the results are relatively unsatisfactory because it is very expensive and the plasmapheresis has to be performed on a regular basis.  

“The drug Juxtapid, as currently evaluated, has led to a dramatic reduction in cholesterol values and normal values were achieved in several people. No existing drug is nearly as effective.  

“The drug represents a breakthrough in the treatment of familial homozygous hypercholesterolemia. The fact that it has been approved by the FDA, gives further impetus to the findings,” says Prof. Theron.  

In future further evaluation will be performed in other forms of hypocholesterolemia.  

According to Prof. Theron, the findings of the study, as well as the recent successful FDA evaluation, once again confirms the fact that the UFS’ Cardiology Contract Research Unit is doing outstanding work.  

Since its inception in 1992, the Unit has already been involved in more than 60 multi-centre, international phase 2 and 3 drug studies. Several of these studies, including the abovementioned study, really affected the way in which cardiology functions.  

The UFS’ Cardiology Contract Research Unit is being recognised nationally and internationally for its high quality of work and is constantly approached for their involvement in new studies.  

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