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25 February 2019 | Story Ruan Bruwer
Tharina van der Walt
The hammer thrower Tharina van der Walt is one of several first-class athletes among the first-year students at Kovsies this year. She is the South African U18 champ and record-holder in 2018.

Several top athletes, some of whom were the very best in the country in their respective events at school, have joined Kovsies as first-year students. They already had their first taste of glory as Kovsies when they recently won their events at the first-year meeting.
 
Among these first-years are Jannes Schlebusch (javelin thrower), Joviale Mbisha (sprinter), Colette Uys (discus/shot-put), and Tharina van der Walt (hammer thrower), who have all represented South Africa in the past two years.
 
Schlebusch won the silver medal at the World U18 championships in 2017, but was injured last year. Great things were expected for 2019, but during the first-year meeting he injured his ankle to such an extent that he will have to undergo an operation that would put him on the sideline for the rest of the season.
 
Van der Walt was the South African schools champ in the hammer throw for girls U19 in 2018, when she managed to set up a new school record of 57,83 m. She was ranked fourth at the World U18 champs in 2017. At the same meeting, Mbisha ended 14th in the 100 m.
 
Uys, who participated in the CAA Southern Region Youth and Junior Championships last year, achieved a second place in the discus at the 2018 National Secondary Schools Championships for girls U19. Other first-years who took part in the SA’s last year, are Vicky Oelofse (1 500 m) and Michael Skosana (long jump).
 
They will strengthen Kovsie Athletics, which already boasts a large group of athletes with international experience. Of the 16 athletes who participated internationally last year, only Kesa Molotsane and Lara Orrock will not be in action for the students again.
 
■ Imperium Residence won the men’s division and Arista/Amelia were the ladies’ winners.
 

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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