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23 January 2019 | Story Charlene Stanley | Photo Charlene Stanley
Michele Middle
Michelle Middle, CMO of Farmovs, looks forward to expanding their operations after the UFS acquired 100% shareholding in 2018.

In medical research, there are NO shortcuts.

The journey of a new medicine from lab to pharmacy shelf takes on average at least 10 years.

Michelle Middle’s journey from young medical graduate starting her first job at FARMOVS to becoming the company’s Chief Medical Officer, was more than twice that long. It was a journey that systematically and adequately equipped her to now Co-captain this flagship enterprise through its biggest challenge yet.

Michelle remembers how Farmovs started in 1974 as a research centre in the Department of Pharmacology. After graduating as medical doctor, she joined Farmovs in 1993, shortly before they moved to their current extensive facilities just south of the Sasol Library.

In 2000, international Clinical Research Organization (CRO) giant Parexel acquired a 70% shareholding, and the name changed to Farmovs-Parexel.

“Parexel really invested a lot in infrastructure and technology, bringing facilities here on par with the best in the world,” says Michelle.

Her own journey in medical research took her to George and later to the US and UK, where she held various international executive leadership positions in international companies.

When the UFS acquired a 100% shareholding in Farmovs earlier this year, she came full circle, as she returned to Bloemfontein to spearhead the expansion of patient studies in collaboration with the Faculty of Health Sciences.

“The opportunities we have here are really enormous,” says an excited Michelle.

“We are the only university in the country with this kind of infrastructure. Apart from our state-of-the-art bioanalytical lab, we also have facilities to accommodate close to 100 research participants. We now have 45 years’ experience in advanced medical research, plus established international clients. We can provide pharmaceutical companies with basically everything they need to develop new medicines.”

Another exciting development is that they are expanding their clinical-trial patient population next year from healthy individuals to people suffering from a host of chronic conditions.

“While they are part of our clinical trials, patients gain valuable insight in their own conditions. We also sometimes pick up underlying medical issues they were not even aware of,” says Michelle.

The 150 Farmovs staff members range from doctors and nurses, to technologists, medical writers, and managers. While not technically part of the university staff, they form a valued part of the Bloemfontein Campus community.

News Archive

Researcher works on finding practical solutions to plant diseases for farmers
2017-10-03

 Description: Lisa read more Tags: Plant disease, Lisa Ann Rothman, Department of Plant Sciences, 3 Minute Thesis,  

Lisa Ann Rothman, researcher in the Department of
Plant Sciences.
Photo: Supplied

 


Plant disease epidemics have wreaked havoc for many centuries. Notable examples are the devastating Great Famine in Ireland and the Witches of Salem. 

Plant diseases form, due to a reaction to suitable environments, when a susceptible host and viable disease causal organism are present. If the interactions between these three factors are monitored over space and time the outcome has the ability to form a “simplification of reality”. This is more formally known as a plant disease model. Lisa Ann Rothman, a researcher in the Department of Plant Sciences at the University of the Free State (UFS) participated in the Three Minute Thesis competition in which she presented on Using mathematical models to predict plant disease. 

Forecast models provide promise fighting plant diseases
The aim of Lisa’s study is to identify weather and other driving variables that interact with critical host growth stages and pathogens to favour disease incidence and severity, for future development of risk forecasting models. Lisa used the disease, sorghum grain mold, caused by colonisation of Fusarium graminearum, and concomitant mycotoxin production to illustrate the modelling process. 

She said: “Internationally, forecasting models for many plant diseases exist and are applied commercially for important agricultural crops. The application of these models in a South African context has been limited, but provides promise for effective disease intervention technologies.

Contributing to the betterment of society
“My BSc Agric (Plant Pathology) undergraduate degree was completed in combination with Agrometeorology, agricultural weather science. I knew that I wanted to combine my love for weather science with my primary interest, Plant Pathology. 
“My research is built on the statement of Lord Kelvin: ‘To measure is to know and if you cannot measure it, you cannot improve it’. Measuring the changes in plant disease epidemics allows for these models to be developed and ultimately provide practical solutions for our farmers. Plant disease prediction models have the potential ability to reduce the risk for famers, allowing the timing of fungicide applications to be optimised, thus protecting their yields and ultimately their livelihoods. I am continuing my studies in agriculture in the hope of contributing to the betterment of society.” 

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