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23 January 2019 | Story Charlene Stanley | Photo Charlene Stanley
Michele Middle
Michelle Middle, CMO of Farmovs, looks forward to expanding their operations after the UFS acquired 100% shareholding in 2018.

In medical research, there are NO shortcuts.

The journey of a new medicine from lab to pharmacy shelf takes on average at least 10 years.

Michelle Middle’s journey from young medical graduate starting her first job at FARMOVS to becoming the company’s Chief Medical Officer, was more than twice that long. It was a journey that systematically and adequately equipped her to now Co-captain this flagship enterprise through its biggest challenge yet.

Michelle remembers how Farmovs started in 1974 as a research centre in the Department of Pharmacology. After graduating as medical doctor, she joined Farmovs in 1993, shortly before they moved to their current extensive facilities just south of the Sasol Library.

In 2000, international Clinical Research Organization (CRO) giant Parexel acquired a 70% shareholding, and the name changed to Farmovs-Parexel.

“Parexel really invested a lot in infrastructure and technology, bringing facilities here on par with the best in the world,” says Michelle.

Her own journey in medical research took her to George and later to the US and UK, where she held various international executive leadership positions in international companies.

When the UFS acquired a 100% shareholding in Farmovs earlier this year, she came full circle, as she returned to Bloemfontein to spearhead the expansion of patient studies in collaboration with the Faculty of Health Sciences.

“The opportunities we have here are really enormous,” says an excited Michelle.

“We are the only university in the country with this kind of infrastructure. Apart from our state-of-the-art bioanalytical lab, we also have facilities to accommodate close to 100 research participants. We now have 45 years’ experience in advanced medical research, plus established international clients. We can provide pharmaceutical companies with basically everything they need to develop new medicines.”

Another exciting development is that they are expanding their clinical-trial patient population next year from healthy individuals to people suffering from a host of chronic conditions.

“While they are part of our clinical trials, patients gain valuable insight in their own conditions. We also sometimes pick up underlying medical issues they were not even aware of,” says Michelle.

The 150 Farmovs staff members range from doctors and nurses, to technologists, medical writers, and managers. While not technically part of the university staff, they form a valued part of the Bloemfontein Campus community.

News Archive

Scientists discover a water reservoir beneath the Free State
2009-12-09

Dr Holger Sommer

The Mantle Research Group Bloemfontein (MRGB), under the leadership of Dr Holger Sommer, a senior lecturer in the Department of Geology at the University of the Free State (UFS), has discovered an enormous water reservoir 160 km beneath the Free State.

This discovery, according to Dr Sommer, is the first of its kind in South Africa after he had previously made a similar finding in Colorado, USA.

However, this water cannot be used for human consumption. “It is not frozen water; it is not molecular water; it is not fresh water; it is not salty water; it is OH – water which is sitting in the crystal lattice,” he said.

He said the reservoir was comparable in size to Lake Victoria in Tanzania.
The researchers collected eclogites from the Roberts Victor (Rovic) Mine close to the town of Boshof, south-west of the Free State, for their study.

“The Rovic eclogites are rocks which represent former oceanic crust transported into the earth’s interior by complex plate tectonic processes about 2.0 billion years ago,” explained Dr Sommer.

“These rocks were finally carried back to the earth’s surface by volcanic (kimberlite) eruptions around 130 million years ago. Eclogitic rocks are therefore a window into the Earth’s interior.”

The question from the beginning for all MRGB scientists was: Is there water inside these rocks in such depth, and if so, where is it located?

To answer this question, Dr Sommer and his research fellows separated single mineral grains from eclogite samples and prepared about 100 micrometer (0,1 mm) thick rock sections. Afterwards, specific particle accelerator (Synchrotron) measurements were carried out in the city of Karlsruhe in Germany.

“And indeed, the MRGB found water inside the studied rocks from the Roberts Victor Mine,” he said. “The water was located in defect structures in crystal lattices and along boundaries between single mineral grains.”

“The occurrence of water at such depth would give first evidence that all water of the oceans could be stored five to ten times in the earth’s mantle.”
The study was conducted about a year ago.
 

Media Release
Issued by: Mangaliso Radebe
Assistant Director: Media Liaison
Tel: 051 401 2828
Cell: 078 460 3320
E-mail: radebemt.stg@ufs.ac.za
4 December 2009

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