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23 January 2019 | Story Charlene Stanley | Photo Charlene Stanley
Michele Middle
Michelle Middle, CMO of Farmovs, looks forward to expanding their operations after the UFS acquired 100% shareholding in 2018.

In medical research, there are NO shortcuts.

The journey of a new medicine from lab to pharmacy shelf takes on average at least 10 years.

Michelle Middle’s journey from young medical graduate starting her first job at FARMOVS to becoming the company’s Chief Medical Officer, was more than twice that long. It was a journey that systematically and adequately equipped her to now Co-captain this flagship enterprise through its biggest challenge yet.

Michelle remembers how Farmovs started in 1974 as a research centre in the Department of Pharmacology. After graduating as medical doctor, she joined Farmovs in 1993, shortly before they moved to their current extensive facilities just south of the Sasol Library.

In 2000, international Clinical Research Organization (CRO) giant Parexel acquired a 70% shareholding, and the name changed to Farmovs-Parexel.

“Parexel really invested a lot in infrastructure and technology, bringing facilities here on par with the best in the world,” says Michelle.

Her own journey in medical research took her to George and later to the US and UK, where she held various international executive leadership positions in international companies.

When the UFS acquired a 100% shareholding in Farmovs earlier this year, she came full circle, as she returned to Bloemfontein to spearhead the expansion of patient studies in collaboration with the Faculty of Health Sciences.

“The opportunities we have here are really enormous,” says an excited Michelle.

“We are the only university in the country with this kind of infrastructure. Apart from our state-of-the-art bioanalytical lab, we also have facilities to accommodate close to 100 research participants. We now have 45 years’ experience in advanced medical research, plus established international clients. We can provide pharmaceutical companies with basically everything they need to develop new medicines.”

Another exciting development is that they are expanding their clinical-trial patient population next year from healthy individuals to people suffering from a host of chronic conditions.

“While they are part of our clinical trials, patients gain valuable insight in their own conditions. We also sometimes pick up underlying medical issues they were not even aware of,” says Michelle.

The 150 Farmovs staff members range from doctors and nurses, to technologists, medical writers, and managers. While not technically part of the university staff, they form a valued part of the Bloemfontein Campus community.

News Archive

Fire as a management tool questionable in arid and semi-arid grassland areas
2015-03-24

Wild fire in the grassland
Photo: Supplied


The influence of fire on the ecosystem in the higher rainfall ‘‘sour’’ grassland areas of southern Africa has been well established. However, less information is available for arid and semi-arid ‘‘sweet’’ grassland areas, says Prof Hennie Snyman, Professor in the Department of Animal, Wildlife, and Grassland Sciences, about his research on the short-term impact of fire on the productivity of grasslands in semi-arid areas.

Sour and sweet grassland areas can be defined as receiving either higher or lower than approximately 600 mm of rainfall respectively. In quantifying the short-term impact of fire on the productivity of grasslands in semi-arid areas, a South African case study (experimental plot data) was investigated.

“Burned grassland can take at least two full growing seasons to recover in terms of above- and below-ground plant production and of water-use efficiency (WUE). The initial advantage in quality (crude protein) accompanying fire does not neutralise the reduction in half of the above-ground production and poor WUE occurring in the first season following the fire.

“The below-ground growth is more sensitive to burning than above-ground growth. Seasonal above-ground production loss to fire, which is a function of the amount and distribution of rainfall, can vary between 238 and 444 kg ha -1 for semi-arid grasslands. The importance of correct timing in the utilisation of burned semi-arid grassland, with respect to sustained high production, cannot be overemphasised,” said Prof Snyman.

In arid and semi-arid grassland areas, fire as a management tool is questionable if there is no specific purpose for it, as it can increase ecological and financial risk management in the short term.

Prof Snyman said: “More research is needed to quantify the impact of runaway fires on both productivity and soil properties, in terms of different seasonal climatic variations. The information to date may already serve as valuable guidelines regarding grassland productivity losses in semi-arid areas. These results can also provide a guideline in claims arising from unforeseen fires, in which thousands of rands can be involved, and which are often based on unscientific evidence.”

For more information or enquiries contact news@ufs.ac.za

 

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