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23 January 2019 | Story Charlene Stanley | Photo Charlene Stanley
Michele Middle
Michelle Middle, CMO of Farmovs, looks forward to expanding their operations after the UFS acquired 100% shareholding in 2018.

In medical research, there are NO shortcuts.

The journey of a new medicine from lab to pharmacy shelf takes on average at least 10 years.

Michelle Middle’s journey from young medical graduate starting her first job at FARMOVS to becoming the company’s Chief Medical Officer, was more than twice that long. It was a journey that systematically and adequately equipped her to now Co-captain this flagship enterprise through its biggest challenge yet.

Michelle remembers how Farmovs started in 1974 as a research centre in the Department of Pharmacology. After graduating as medical doctor, she joined Farmovs in 1993, shortly before they moved to their current extensive facilities just south of the Sasol Library.

In 2000, international Clinical Research Organization (CRO) giant Parexel acquired a 70% shareholding, and the name changed to Farmovs-Parexel.

“Parexel really invested a lot in infrastructure and technology, bringing facilities here on par with the best in the world,” says Michelle.

Her own journey in medical research took her to George and later to the US and UK, where she held various international executive leadership positions in international companies.

When the UFS acquired a 100% shareholding in Farmovs earlier this year, she came full circle, as she returned to Bloemfontein to spearhead the expansion of patient studies in collaboration with the Faculty of Health Sciences.

“The opportunities we have here are really enormous,” says an excited Michelle.

“We are the only university in the country with this kind of infrastructure. Apart from our state-of-the-art bioanalytical lab, we also have facilities to accommodate close to 100 research participants. We now have 45 years’ experience in advanced medical research, plus established international clients. We can provide pharmaceutical companies with basically everything they need to develop new medicines.”

Another exciting development is that they are expanding their clinical-trial patient population next year from healthy individuals to people suffering from a host of chronic conditions.

“While they are part of our clinical trials, patients gain valuable insight in their own conditions. We also sometimes pick up underlying medical issues they were not even aware of,” says Michelle.

The 150 Farmovs staff members range from doctors and nurses, to technologists, medical writers, and managers. While not technically part of the university staff, they form a valued part of the Bloemfontein Campus community.

News Archive

Water erosion research help determine future of dams
2017-03-07

Description: Dr Jay le Roux Tags: Dr Jay le Roux

Dr Jay le Roux, one of 31 new NRF-rated
researchers at the University of the Free State,
aims for a higher rating from the NRF.
Photo: Rulanzen Martin

“This rating will motivate me to do more research, to improve outcomes, and to aim for a higher C-rating.” This was the response of Dr Jay le Roux, who was recently graded as an Y2-rated researcher by the National Research Foundation (NRF).

Dr Le Roux, senior lecturer in the Department of Geography at the University of the Free State (UFS), is one of 31 new NRF-rated researchers at the UFS. “This grading will make it possible to focus on more specific research during field research and to come in contact with other experts. Researchers are graded on their potential or contribution in their respective fields,” he said.

Research assess different techniques
His research on water erosion risk in South Africa (SA) is a methodological framework with three hierarchal levels presented. It was done in collaboration with the University of Pretoria (UP), Water Research Commission, Department of Agriculture, Forestry and Fisheries, and recently Rhodes University and the Department of Environmental Affairs. Dr Le Roux was registered for 5 years at UP, while working full-time for the Agricultural Research Council – Institute for Soil, Climate and Water (ARC-ISCW).

Water erosion risk assessment in South Africa: towards a methodological framework
, illustrates the most feasible erosion assessment techniques and input datasets that can be used to map water erosion features in SA. It also emphasises the simplicity required for application at a regional scale, with proper incorporation of the most important erosion-causal factors.

The main feature that distinguishes this approach from previous studies is the fact that this study interprets erosion features as individual sediment sources. Modelling the sediment yield contribution from gully erosion (also known as dongas) with emphasis on connectivity and sediment transport, can be considered as an important step towards the assessment of sediment produce at regional scale. 
 
Dams a pivotal element in river networks

Soil is an important, but limited natural resource in SA. Soil erosion not only involves loss of fertile topsoil and reduction of soil productivity, but is also coupled with serious off-site impacts related to increased mobilisation of sediment and delivery to rivers.

The siltation of dams is a big problem in SA, especially dams that are located in eroded catchment areas. Dr Le Roux recently developed a model to assess sediment yield contribution from gully erosion at a large catchment scale. “The Mzimvubu River Catchment is the only large river network in SA on record without a dam.” The flow and sediment yield in the catchment made it possible to estimate dam life expectancies on between 43 and 55 years for future dams in the area.
 
Future model to assess soil erosion
“I plan to finalise a soil erosion model that will determine the sediment yield of gully erosion on a bigger scale.” It will be useful to determine the lifespan of dams where gully erosion is a big problem. Two of his PhD students are currently working on project proposals to assess soil erosion with the help of remote sensing techniques.

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