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23 January 2019 | Story Charlene Stanley | Photo Charlene Stanley
Michele Middle
Michelle Middle, CMO of Farmovs, looks forward to expanding their operations after the UFS acquired 100% shareholding in 2018.

In medical research, there are NO shortcuts.

The journey of a new medicine from lab to pharmacy shelf takes on average at least 10 years.

Michelle Middle’s journey from young medical graduate starting her first job at FARMOVS to becoming the company’s Chief Medical Officer, was more than twice that long. It was a journey that systematically and adequately equipped her to now Co-captain this flagship enterprise through its biggest challenge yet.

Michelle remembers how Farmovs started in 1974 as a research centre in the Department of Pharmacology. After graduating as medical doctor, she joined Farmovs in 1993, shortly before they moved to their current extensive facilities just south of the Sasol Library.

In 2000, international Clinical Research Organization (CRO) giant Parexel acquired a 70% shareholding, and the name changed to Farmovs-Parexel.

“Parexel really invested a lot in infrastructure and technology, bringing facilities here on par with the best in the world,” says Michelle.

Her own journey in medical research took her to George and later to the US and UK, where she held various international executive leadership positions in international companies.

When the UFS acquired a 100% shareholding in Farmovs earlier this year, she came full circle, as she returned to Bloemfontein to spearhead the expansion of patient studies in collaboration with the Faculty of Health Sciences.

“The opportunities we have here are really enormous,” says an excited Michelle.

“We are the only university in the country with this kind of infrastructure. Apart from our state-of-the-art bioanalytical lab, we also have facilities to accommodate close to 100 research participants. We now have 45 years’ experience in advanced medical research, plus established international clients. We can provide pharmaceutical companies with basically everything they need to develop new medicines.”

Another exciting development is that they are expanding their clinical-trial patient population next year from healthy individuals to people suffering from a host of chronic conditions.

“While they are part of our clinical trials, patients gain valuable insight in their own conditions. We also sometimes pick up underlying medical issues they were not even aware of,” says Michelle.

The 150 Farmovs staff members range from doctors and nurses, to technologists, medical writers, and managers. While not technically part of the university staff, they form a valued part of the Bloemfontein Campus community.

News Archive

Oxford professor unlocks secrets of DNA
2017-03-31

Description: Oxford professor unlocks secrets of DNA Tags: Oxford professor unlocks secrets of DNA

From left are: Dr Cristian Capelli, Associate Professor
of Human Evolution at Oxford University;
Dr Karen Ehlers, Senior Lecturer and Prof Paul Grobler,
both from the Department of Genetics at the UFS.
Photo: Siobhan Canavan

Many people are interested to know more about their history and origins, and with the help of genetics, it is possible to provide more information about one’s roots.

During a lecture at the Department of Genetics at the University of the Free State (UFS), Dr Cristian Capelli, Associate Professor of Human Evolution at Oxford University in the UK, addressed staff members and students on the history of our species.

Reconstructing the history of human population
With his research, titled: People on the move: population structure and gene-flow in Southern Africa, Dr Capelli looks at reconstructing the history of human populations, focusing mainly on how the different human populations are related, as well as how they exchange genes.

He said this research could be of great significance to the medical field too. “Knowing what the genetic make-up of individuals is, can give us some information about their susceptibility to diseases, or how they would react to a given medicine. Therefore, this knowledge can be used to inform health-related policies.”

Combining individual histories of multiple people
To understand this research more clearly, Dr Capelli explained it in terms of DNA and how every individual receives half of their DNA from their mother and half from their father just as their parents had received theirs from their parents. And so it goes from generation after generation. Each individual stores a part of their ancestors’ DNA which makes up the individual genetic history of each person.

“If we combine these individual histories by looking at the DNA of multiple people, we can identify the occurrences that are shared across individuals and therefore reconstruct the history of a population, and in the same way on a larger scale, the history of our own species, homo sapiens.

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