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24 January 2019 | Story Zama Feni | Photo Barend Nagel
Prof Matlabisa
Prof Motlalepula Matlabisa of the Department of Pharmacology.

Two South African government departments have granted the University of the Free State’s Department of Pharmacology a combined amount of R15 million for the establishment of four tea farms in the disadvantaged communities in the North West and Eastern Cape Communities.

The head of the project Prof Motlalepula Matsabisa at the Department of Pharmacology said that that Department of Environmental Affairs (DEA) has granted an amount of R10 million for the community research in the respective provinces.

This grant is a top up to the R5 million they received from the Department of Science and Technology for the “community implementation on indigenous health infusions or teas as commonly known.”

The DEA will in the near future sign a Memorandum of Agreement (MOA) with the university.


Tea project set to empower communities


“The project is to implement and build structures in the four communities we work with in the North West and Eastern Cape,” he said.

The identified areas for the project are in the Eastern Cape towns of Alice and Idutywa as well another two North West communities in Zeerust.

Prof Matsabisa indicated that the project will be a manifestation of “how science can contribute to economic growth, poverty alleviation and job creation.” 

“It was very interesting to have discovered that some French and German companies have already displayed interest in the projects,” he said.

He stated that a project of this nature is a good initiative by the UFS and it will also show that the university’s research activities are national. “We have been researching and developing indigenous teas which have now attracted interest locally and internationally by huge companies such as Nestle, Tiger Brands, Moringa World etc,” he said. 


Taking it slowly


At the initial stages of the tea farming project, Prof Matsabisa said they would start in small portions of utilising five hectares in each of the four projects and as the project gains momentum, they would expand.

Prof Matlabisa said that an environmental impact assessment has already been conducted and they were waiting for the DEA to give them a go ahead for the land preparations.



News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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