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14 January 2019 | Story Thabo Kessah | Photo Thabo Kessah
Dr Lisa Komoreng
Dr Lisa Komoreng’s research highlights traditional medicinal plant qualities used to deal with diseases like TB and elephantiasis.

The burden that diseases like tuberculosis (TB), lymphatic filariasis (elephantiasis), sexually transmitted infections (STIs), skin infections, and ear, nose and throat (ENT) infections bring to the country, mainly poverty-stricken communities, has prompted Dr Lisa Komoreng to focus her research on traditional medicinal plants.

 

South Africa, says Dr Komoreng, has the third highest number of reported cases and the fifth highest number of estimated prevalent cases, with the second highest burden of drug-resistant TB cases in the world amongst the 22 high-burden countries.

South Africa is burdened
by elephantiasis and treating
it remains a huge problem,
says Dr Lisa Komoreng.

 

“According to the Free State Provincial Strategic Plan (2012-2016), HIV and TB are the leading causes of death in the Province, with TB being the second most leading cause. Our country is also burdened by elephantiasis and treating it remains a huge problem. Patients are often turned away from some of the public hospitals, reasons being that there is no treatment in the country or that the disease needs specialist care. It with this in mind that my research focuses on providing treatment that is cheaper than western medicine, easily accessible, with fewer or no side effects,” she said.

 

“People suffering from elephantiasis are not only physically disabled, but they suffer mental, social and financial losses contributing to stigma and poverty. Some of the drugs used to treat the disease are ineffective against adult parasitic worms, which are the ones that cause the disease, and they also have side effects. Our research in dealing with these diseases enables us to work hand-in-hand with herbalists, traditional healers and people who have indigenous knowledge about the use of traditional medicine. We consult with them in order to acquire information about the medicinal plants that are used to treat and manage those diseases. Once they provide us with information, we collect the plant species together, which we subsequently take to the University herbarium for proper identification of their scientific names and to the laboratory for experiments,” she added.

 

Dr Komoreng is a Senior Lecturer in the Department of Plant Sciences at the Qwaqwa Campus. She has authored and co-authored over 15 research articles and has presented her research at various national and international conferences.  Her research team comprises of 5 MSc and 4 PhD students.

 

The Thuthuka NRF Rating Track (2015 – 2017 and 2018 – 2020) funds the research project on elephantiasis.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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