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14 January 2019 | Story Thabo Kessah | Photo Thabo Kessah
Dr Lisa Komoreng
Dr Lisa Komoreng’s research highlights traditional medicinal plant qualities used to deal with diseases like TB and elephantiasis.

The burden that diseases like tuberculosis (TB), lymphatic filariasis (elephantiasis), sexually transmitted infections (STIs), skin infections, and ear, nose and throat (ENT) infections bring to the country, mainly poverty-stricken communities, has prompted Dr Lisa Komoreng to focus her research on traditional medicinal plants.

 

South Africa, says Dr Komoreng, has the third highest number of reported cases and the fifth highest number of estimated prevalent cases, with the second highest burden of drug-resistant TB cases in the world amongst the 22 high-burden countries.

South Africa is burdened
by elephantiasis and treating
it remains a huge problem,
says Dr Lisa Komoreng.

 

“According to the Free State Provincial Strategic Plan (2012-2016), HIV and TB are the leading causes of death in the Province, with TB being the second most leading cause. Our country is also burdened by elephantiasis and treating it remains a huge problem. Patients are often turned away from some of the public hospitals, reasons being that there is no treatment in the country or that the disease needs specialist care. It with this in mind that my research focuses on providing treatment that is cheaper than western medicine, easily accessible, with fewer or no side effects,” she said.

 

“People suffering from elephantiasis are not only physically disabled, but they suffer mental, social and financial losses contributing to stigma and poverty. Some of the drugs used to treat the disease are ineffective against adult parasitic worms, which are the ones that cause the disease, and they also have side effects. Our research in dealing with these diseases enables us to work hand-in-hand with herbalists, traditional healers and people who have indigenous knowledge about the use of traditional medicine. We consult with them in order to acquire information about the medicinal plants that are used to treat and manage those diseases. Once they provide us with information, we collect the plant species together, which we subsequently take to the University herbarium for proper identification of their scientific names and to the laboratory for experiments,” she added.

 

Dr Komoreng is a Senior Lecturer in the Department of Plant Sciences at the Qwaqwa Campus. She has authored and co-authored over 15 research articles and has presented her research at various national and international conferences.  Her research team comprises of 5 MSc and 4 PhD students.

 

The Thuthuka NRF Rating Track (2015 – 2017 and 2018 – 2020) funds the research project on elephantiasis.

News Archive

Nanotechnology breakthrough at UFS
2010-08-19

 Ph.D students, Chantel Swart and Ntsoaki Leeuw


Scientists at the University of the Free State (UFS) made an important breakthrough in the use of nanotechnology in medical and biological research. The UFS team’s research has been accepted for publication by the internationally accredited Canadian Journal of Microbiology.

The UFS study dissected yeast cells exposed to over-used cooking oil by peeling microscopically thin layers off the yeast cells through the use of nanotechnology.

The yeast cells were enlarged thousands of times to study what was going on inside the cells, whilst at the same time establishing the chemical elements the cells are composed of. This was done by making microscopically small surgical incisions into the cell walls.

This groundbreaking research opens up a host of new uses for nanotechnology, as it was the first study ever in which biological cells were surgically manipulated and at the same time elemental analysis performed through nanotechnology. According to Prof. Lodewyk Kock, head of the Division Lipid Biotechnology at the UFS, the study has far reaching implications for biological and medical research.

The research was the result of collaboration between the Department of Microbial, Biochemical and Food Biotechnology, the Department of Physics (under the leadership of Prof. Hendrik Swart) and the Centre for Microscopy (under the leadership of Prof.Pieter van Wyk).

Two Ph.D. students, Chantel Swart and Ntsoaki Leeuw, overseen by professors Kock and Van Wyk, managed to successfully prepare yeast that was exposed to over-used cooking oil (used for deep frying of food) for this first ever method of nanotechnological research.

According to Prof. Kock, a single yeast cell is approximately 5 micrometres long. “A micrometre is one millionth of a metre – in laymen’s terms, even less than the diameter of a single hair – and completely invisible to the human eye.”

Through the use of nanotechnology, the chemical composition of the surface of the yeast cells could be established by making a surgical incision into the surface. The cells could be peeled off in layers of approximately three (3) nanometres at a time to establish the effect of the oil on the yeast cell’s composition. A nanometre is one thousandth of a micrometre.

Each cell was enlarged by between 40 000 and 50 000 times. This was done by using the Department of Physics’ PHI700 Scanning Auger Nanoprobe linked to a Scanning Electron Microscope and Argon-etching. Under the guidance of Prof. Swart, Mss. Swart en Leeuw could dissect the surfaces of yeast cells exposed to over-used cooking oil. 

The study noted wart like outgrowths - some only a few nanometres in diameter – on the cell surfaces. Research concluded that these outgrowths were caused by the oil. The exposure to the oil also drastically hampered the growth of the yeast cells. (See figure 1)  

Researchers worldwide have warned about the over-usage of cooking oil for deep frying of food, as it can be linked to the cause of diseases like cancer. The over-usage of cooking oil in the preparation of food is therefore strictly regulated by laws worldwide.

The UFS-research doesn’t only show that over-used cooking oil is harmful to micro-organisms like yeast, but also suggests how nanotechnology can be used in biological and medical research on, amongst others, cancer cells.

 

Figure 1. Yeast cells exposed to over-used cooking oil. Wart like protuberances/ outgrowths (WP) is clearly visible on the surfaces of the elongated yeast cells. With the use of nanotechnology, it is possible to peel off the warts – some with a diameter of only a few nanometres – in layers only a few nanometres thick. At the same time, the 3D-structure of the warts as well as its chemical composition can be established.  

Media Release
Issued by: Mangaliso Radebe
Assistant Director: Media Liaison
Tel: 051 401 2828
Cell: 078 460 3320
E-mail: radebemt@ufs.ac.za  
18 August 2010
 

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