Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
24 May 2019 | Story Eloise Calitz | Photo Charl Devenish
Gangster book Discussion
From left: Jacques van Wyk from the Association of Certified Fraud Examiners (ACFE) Cathy Dlodlo, news editor from OFM; Pieter Roux from the UFS Business School; Alta Vermeulen from the UFS Department of Political Studies and Governance and Pieter-Louis Myburgh, author

A packed Odeion Auditorium at the University of the Free State was welcomed by Professor Helena van Zyl, Head of the UFS Business School. The reason being, a panel discussion with award-winning investigative reporter and author, Pieter-Louis Myburgh, on his much-publicised book Gangster State: Unravelling Ace Magashule's Web of Capture. The programme took the form of a panel discussion. The panellists included Pieter-Louis Myburgh, author; Jacques van Wyk from the Association of Certified Fraud Examiners (ACFE); Cathy Dlodlo, news editor from OFM; Alta Vermeulen from the UFS Department of Political Studies and Governance; and Pieter Roux from the UFS Business School.

In his introduction, Myburgh said he was happy that he was able to come to Bloemfontein and have the discussion, since South Africans should cherish freedom of speech and a free press.

The research for the book took 13 months to conclude, and during this time he spent a lot of time in the Free State and Bloemfontein. He mentioned that the book gave him the opportunity to present a condensed account of what he discovered; he could therefore share more, as opposed to just reporting on a story in the newspaper. For him, investigative reporting should always be fact based and open to scrutiny.

Some of the topics raised by the panel was concern about the perception that investigative journalists are focusing more on corruption in the public sector and less on the private sector. This was, however, discarded as a myth, as Myburgh pointed out that he exposed both private and public sector dealings in order to provide the full scope of involved parties.

Focusing on whistle blowers, the panel challenged the verification of whistle-blower information. Myburgh responded that journalists never use only one whistle-blower’s evidence, since that is merely the start of the investigation. Further investigation was necessary, and facts had to be verified. With that said, there is still a lot to be done with regard to the protection of whistle-blowers, he concluded.

The floor was opened to the audience, which provided the opportunity to ask questions and raise concerns about what was mentioned during the panel discussion. The audience eagerly participated in the discussion. In conclusion, Myburgh reiterated that society plays a vital role in keeping those in power to the promises they make.

After the discussion, the audience had the opportunity to have their books signed by the author.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept