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06 November 2019 | Story Legopheng Maphile | Photo Legopheng Maphile
Best assigment winners
At the prize-giving were from the left, front: Christoffel de Lange and Ms Nombulelo Shange (who accepted the prize won by De Haan). Back row, from the left: Prof Neil Heideman, Professor in the Department of Zoology and Entomology; and Betsy Eister, UFS LIS Director.

The University of the Free State Library and Information Services (UFS LIS) is partnering with faculties in acknowledging top-performing students at the university. Together with the Faculties of the Humanities and Natural and Agricultural Sciences, the Best Assignment project was launched – meant to inspire, motivate, and encourage students to put extra effort into producing assignments of high quality.

Legopheng Maphile, Assistant Director: Library Marketing and Community Engagement at UFS LIS, says the project is meant to harness and nurture undergraduate research in line with the university’s research-led vision. 

“There are requirements as to how assignments should be presented. This demonstrates the level of knowledge acquisition and academic writing skills. The library contributes to this activity by training students in library research skills to access scholarly, academic, specialist, and expert information resources to support academic excellence. This is a collaborative practice between the library and academics.

“In 2019, only third-year assignments were considered in a pilot project, and at this stage, students are expected to understand what is required for writing assignments.”

Recognising the effort that students put into their assignments, the UFS LIS, in collaboration with the Departments of Sociology and Zoology and Entomology, recently handed out prizes of R2 500 to deserving students. 

Johandré J de Haan and Christoffel de Lange each received gift vouchers to the value of R1 250, courtesy of Van Schaik and Sherwood Books, in collaboration with Juta and Oxford University Press. De Haan was recognised for his assignment titled Marx and the impact of his theoretical concepts in the South African context and its relevancy and De Lange received a nod for his Differences in Heat Uptake Rate between White and Black Sand-filled Cans of Similar Size. 

Legopheng says going forward, the best undergraduate research assignments will be considered for publication in the Kovsie Undergraduate Research Journal, the library’s open-access journal that is being developed. 


News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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