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12 November 2019 | Story Leonie Bolleurs | Photo Leonie Bolleurs
Farmovs
At a first for South Africa, the SACRA clinical trials capacity-building workshop with government, research institutions, and industry, were from the left: Dr Nathaniel Mofolo, Dr Rita Nathan, Dr Mojalefa Maseloa (Head: Clinical Services in the Clinical Unit at the Universitas Hospital) and Sue Baily (Site Management Head at IQVIA).

Whether it is to treat the flu or a more serious illness, all medicines go through a very costly and lengthy research process before being approved for prescription to patients. The cumulative time from the beginning of trials to marketing approval has increased over the past ten years. 

According to Dr Vathi Papu-Zamxaka from the South African Clinical Research Association (SACRA), South Africans would not have had access to safe and effective medicines, had it not been for the intensive research conducted on new medicines. 

On 7 November 2019, a group of 115 delegates representing the Free State Department of Health, the UFS, private research sites, and the pharmaceutical industry met at FARMOVS on the Bloemfontein Campus of the University of the Free State (UFS) for the SACRA clinical trials capacity-building workshop.

2,1 billion dollars to develop one successful drug

Dr Michelle Middle, Chief Medical Officer at FARMOVS, provided some interesting stats on the process for drugs to hit the shelves: “One out of 10 drugs entering human research will be approved. The cost of development of one successful drug is approximately 2,1 billion dollars. And the time to develop a drug, from submission of the Investigational New Drug Application (IND) to approval by the Food and Drug Administration (FDA), is between 12 and 15 years.”

Dr Middle stated that drug development is one of the most regulated processes, with ethics and patient safety governing the undertaking. “With SAHPRA (South African Health Products Regulatory Agency) having some of the strictest regulations in the world, South Africa has a good history of running trials.  In addition, fast growth is expected for the pharmaceutical market on the African continent, necessitating the need for increased clinical trials on this continent,” she said. 

Very few clinical trials hosted in South Africa 

Although Africa has the broadest genetic variability of all human populations and carries 17% of the global population, very few clinical trials are hosted on the continent. Globally, there are currently approximately 322 000 clinical trials being actively conducted, of which only 1 700 are conducted in Africa, i.e. less than 3%.  Even worse, only 304 of the 1 700 trials running in Africa are conducted in South Africa.  There is thus a critical need for South Africa as a country to market itself as a clinical trial destination and to attract more trials to the country.

South Africa’s competitive edge lies in being known for its ICH (International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use)-compliant top-quality research, racial and genetic diverse trial participants, good medical infrastructure and expertise, and the good reputation of the regulator (SAHPRA). “There are, however, a need for transformation and capacity building in clinical research in the country,” said Dr Middle. 

Dr Rita Nathan, Head of Clinical Services in the Clinical Department at the Universitas Hospital, who was representing government at the workshop, is looking to strengthen clinical trials across government and industry by focusing on, among others, funding models, operations management, and service delivery. 

From the UFS Faculty of Health Sciences, Dr Nathaniel Mofolo, Head of the School of Clinical Medicine, said collaboration between stakeholders is important. “This initiative is giving direction to the UFS vision of being a research-led university.” 

Other topics discussed at the workshop include the clinical trials landscape, how clinical trials work, the patient factor, ethics in clinical trials, and the economic aspect of clinical trials. 

News Archive

RSG Crossword Tournament helps to celebrate language
2016-07-27

Description: RSG Crossword Tournament  Tags: RSG Crossword Tournament

Dr Annette de Wet (left), Assistant Director
of the Unit for Language Development in
the Centre for Teaching and Learning at
the UFS, Albe Grobbelaar from XWord,
Prof Angelique van Niekerk, Head of the
Department of Afrikaans and Dutch, German
and French, and Prof Lucius Botes, Dean of the
Faculty of the Humanities, during the launch
of the RSG Crossword Tournament.
Photo: Jóhann Thormählen

Sometimes it is difficult for language departments to be topical and to show their relevance for the people out there. However, with the RSG Crossword Tournament, this became possible and Afrikaans could be celebrated in a positive manner. This is what Prof Angelique van Niekerk, Head of the Department of Afrikaans and Dutch, German and French at the University of the Free State (UFS), had to say about this initiative.

Interest during the Vrystaat Arts Festival exceeded all expectations. Altogether, 46 participants from across the country participated on 15 and 16 July 2016. Ilse van Hemert from Pretoria was crowned as the first South African crossword champion.

New dimension to language milieu

Prof Van Niekerk said people are familiar with crossword puzzles from the media, and it was the first time that a tournament like this was presented to the public in South Africa. “This tournament brings something like linguistics and linguistic sensitivity to the fore,” she said. “It is another dimension of the language milieu.” This is exactly why her department would like to see it grow in future.

Wordplay serves as inspiration

The idea for the tournament is based loosely on the film, Wordplay (2006), which is set in New York, and the annual New York Times Crossword Tournament. The South African Tournament was presented in conjunction with the crossword group, XWord, Prof Van Niekerk’s department, and the radio station RSG as brand sponsor.

Crossword puzzles and blockbusters crosswords completed

“This tournament brings something like
linguistics and linguistic sensitivity to
the fore.”


Albe Grobbelaar from XWord said the winners were determined on a points basis. “Competitors had to complete two crossword puzzles and one blockbuster crossword. The difference between the two is that a blockbuster’s clues are within the blocks or grid, but with the crossword, you have white and black blocks with the clues separate on the outside.”

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