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09 October 2019 | Story Xolisa Mnukwa | Photo Barend Nagel
Braille Signage
Big on Braille: Members of the Kovsie community who are living with visual impairments can now access directions through the new braille system.

The University of the Free State (UFS) commemorate World Sight Day, which is celebrated annually on the second Thursday of October. The day has been set aside and aimed at drawing attention to blindness and vision. This was originally initiated by the #SightFirstCampaign of the Lions Club International Foundation in 2000. 
The university aims to contribute to the development and social justice of all students through the production of globally competitive graduates. Thus, the development and implementation of co-curricular programmes, activities, services, and mutual infrastructure will allow for humanising daily lived experiences among students, which are essential for universal access, student academic success, social behaviour, engagement, and an inclusive institutional culture.

With this in mind, the university rolled out a capital project that included the construction of tactile pathways with braille indicators on the pathways, designed to support and caution pedestrians who are blind or visually impaired. The indicators are universally accessible, because it includes Braille and text. The text then gives indications to new students who are also struggling to find their way around campus.

A UFS Bachelor of Social Sciences student who dreams of becoming a social worker, Tshegofatso Nkatlholang, who was born partially blind, but is now completely blind is motivated by the prospect of living a life where she has the ability to help the less fortunate. Her opinion of the construction and implementation of the new tactile pathways on the UFS Bloemfontein Campus is that they are extremely helpful. She went on to say, “That is my road, and I am grateful for a university that strives to operate an inclusive infrastructural environment where I don’t feel sidelined.”
Kovsie student Keamogetswe Mbele was born partially blind with very low vision, eventually losing her eyesight. She explained that she had no knowledge of the newly built braille indicators on the tactile pathways, but that she felt appreciative of the university’s initiative to constitute an inclusive academic and infrastructural environment for all students on campus. Motivated by her personal goals of independence and financial freedom, ‘Kamo’, as her peers refer to her, is determined to live a prosperous academic life throughout the course of her studies at the UFS.

According to Mookgo Moloi, a Kovsie student who was not born blind but gradually lost her sight at the age of 15, said, “Life on campus is very caring”. She reflected on the opportunities, as well as the technical and emotional support that the Center for Universal Access and Disability Support (CUADS) has provided her, which has made her academic career a lot easier, and more advantageous for her to graduate. 
CUADS further strives to facilitate, create opportunities, and enhance students’ understanding of multiple intersections and ways of being that are consistent with human rights and the principles of social justice.




News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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