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17 September 2019 | Story Valentino Ndaba | Photo Valentino Ndaba
Diversity festival
Staff and students come together in celebration at the International Cultural Diversity Festival.


There are 195 countries in the world and the University of the Free State (UFS) officially has a personal relationship with 24 of them. Be it through exchange inbound or outbound programmes or research collaboration, Kovsies is growing its global footprint.

The 2019 International Cultural Diversity Festival brought a mix of music, dance, and poetry to the Bloemfontein Campus on Friday 13 September 2019. The aim of the festival was to recognise, appreciate and celebrate the diverse cultures represented on all our campuses.

Reeling in and rolling out the best talent pool

As stated in the 2018 Internationalisation Report, “Kovsies currently has about 50 international collaboration agreements, and collaboration with 1 584 institutions,” in terms of research. The plan is to widen researchers’ international networks, with a special focus on the African continent.

Finding strength in diversity

“Diversity within groups at the UFS necessitates that we foster a culture of tolerance and a spirit of mutual acceptance and appreciation at our university,” says Chevon Slambee, Chief Officer at the Office for International Affairs (OIA).

Slambee spoke on behalf of the Vice-Rector: Research and Internationalisation, Prof Corli Witthuhn, and the Director of the OIA, Cornelius Hagenmeier, commending the diversity reflected in our international students and staff community.

She mirrored the views of the Kovsie community at large in calling for an end to division and violence based on “othering”. Referring to the upsurge in violence directed against women and people from other countries that we saw in South Africa last month, Slambee remarked: “We are shocked and speechless in light of these events, which are contrary to the spirit of embracing one another’s humanity, which we believe in and want to promote.”

Content photo International
The International Cultural Diversity was filled with entertainment.

A coming together

The festival theme this year was the Boma which is a traditional space created back in the day where a community would sit around the fire, drumming, singing, dancing and listening to tales told by the elders. The UFS strives to be a similar space – growing the current number of international relationships and immersing the institution in the global village – the African way.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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