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03 August 2020 | Story Nitha Ramnath | Photo Supplied
Prof Ivan Turok.

The University of the Free State is pleased to announce that the Human Sciences Research Council’s (HSRC) Prof Ivan Turok has been awarded a research chair by the South African Research Chairs Initiative (SARChI). Prof Turok is one of South Africa’s most cited social scientists. He will hold the Research Chair in City-Region Economies in the Department of Economics and Finance and the Centre for Development Support at the UFS. The UFS is now home to six SARChI chairs.  

The research chair is the first partnership of its kind between a South African university and the HSRC. The chair will seek to understand how cities can accelerate economic growth and inclusive development in SA. It will analyse why some cities are more successful than others, and what policies and practices can improve conditions for citizens and communities. It will also provide funding to increase research capacity through the appointment of postdoctoral, PhD, and master’s students.

SARChI is a government intervention aimed at strengthening the scientific research and innovation capacity of South African universities. It was established by the Department of Science and Technology in 2006 and is managed by the National Research Foundation (NRF). According to the NRF, its prestigious research chair is awarded to established researchers who are recognised internationally for their research contributions.  

“Prof Turok’s appointment as Research Chair is a great honour for the university. He is a highly rated researcher and his knowledge of city-region economies will be of exceptional value to the university’s research portfolio, as well as to the country’s agenda of transforming urban areas. Our country is in dire need of research in this area, in which Prof Turok will be playing a significant role,” said Prof Francis Petersen, Rector and Vice-Chancellor of the UFS. 

According to Prof Lochner Marais, Head of the UFS Centre for Development Support, the research chair will have four main themes: The Urban System – Demographics and Economics; Economic Sectors in Space; Dynamic Places; and Strategic Urban Assets. The chair brings together research from the Departments of Economics and Finance, Urban and Regional Planning, and the Centre for Development Support. The long-term goal is to develop the chair into a centre of excellence.

“The chair is co-funded by the South African Cities Network. All research will speak directly to the South African Cities Network’s agenda of transforming urban areas in the country,” Prof Marais adds.

In congratulating Prof Turok, the CEO of the Human Sciences Research Council, Prof Crain Soudien, said, “It is fitting that this research chair has been awarded to Prof Turok.  It is a culmination of many years of work in the area of city regions through which he has earned a sterling reputation as a scholar in this area of work.”

Prof Turok has authored more than 150 peer-reviewed publications and 11 books/monographs. He holds an NRF B1-rating and is the former Editor-in-Chief of the top international journal, Regional Studies. He is currently Executive Director: Economic Performance and Development at the Human Sciences Research Council and was Chairman of the Durban City Planning Commission. He was formerly Professor of Urban Economic Development, and Director of Research: Department of Urban Studies at the University of Glasgow. Prof Turok was also a Mellon Fellow at the University of Cape Town and Professor of Urban and Regional Planning at the University of Strathclyde. He is an occasional adviser to the United Nations, OECD, African Development Bank, UNECA, and several national governments. His recent books include Transitions in Regional Economic Development (2018, Routledge), Value Chains in Sub-Saharan Africa (2019, Springer), and Restoring the Core: Central City Decline and Transformation in the South (2020, Elsevier). He has a PhD in Economics from the University of Reading.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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