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06 August 2020 | Story Leonie Bolleurs | Photo Charl Devenish
Poojah Jawallapersand strives for academic excellence and to empower others through research and innovation.

As South Africa commemorates Women’s Day on 9 August 2020 and continues Women’s Month celebrations throughout August, the UFS shines a spotlight on women who are making an impact on our three campuses on a daily basis.

One of these women is Poojah Jawallapersand, a PhD student majoring in Biochemistry. Poojah is part of the Pathogenic Yeast Research Group in the Department of Microbial, Biochemical and Food Biotechnology. 

In her current research study, she is investigating whether fungal yeast cells and components from the opportunistic and fungal pathogen Candida albicans can cause Alzheimer’s disease-like symptoms, and if these symptoms can be effectively treated through drug repositioning. The study is being conducted on zebrafish larvae.

Jawallapersand explains that drug repositioning is a drug development strategy that involves finding alternative indications for existing licensed drugs for novel therapeutic purposes. “In short, the use of old drugs for new uses. There is no cure for Alzheimer’s disease, hence this research will pave the way towards identifying effective treatment options to treat the disease,” she says. 

“Be confident and dare to be yourself because you are worth more than you think.” - Poojah Jawallapersand

An interview with Jawallapersand reveals more about the woman behind this much-needed research study. 

Is there a woman who inspires you and who you would like to celebrate this Women’s Month, and why?

“My mother and Mrs Deeya Domah (my high-school teacher) constantly inspire me and have played a pivotal role in my life. My mother taught me the value of life, encouraged me to embrace my cultural heritage and spirituality, and always urged me to be ‘original’.”

“As a teenager, Mrs Domah introduced me and made me fall in love with the study of life (biology), to the extent that I made a career out of it. She inspired me through her timeless elegance and passion for teaching and learning, her willingness to go the extra mile in helping her students, her role in environmental and ecological sustainability, her support towards the empowerment of women, and her influence as an educator and role model in the lives of numerous individuals.”

What are some challenges you have faced in your life that have made you a better woman?

“Although I have experienced several challenges in my life, the greatest challenge for me is still to master my mind and emotions. It is vital to have a strong support system to overcome these challenges; for me, this has always been my faith, my parents, and my sister. I am glad that I have gone through these trials; they taught me how to deal with some issues, to stay enthusiastic, to appreciate myself, to practice self-love, and to master the art of constantly picking myself up when I fall. I am still a work in progress and strive daily for self-improvement. However, I have become stronger, more resilient, and a better woman because of these challenges.”

What advice would you give to the 15-year-old you?

“Enjoy your adolescence, have fun, make memories, live these moments, and do not rush into adulthood. Stop trying to please other people and learn to say ‘no’. Be confident and dare to be yourself because you are worth more than you think.”

What would you say makes you a champion woman [of the UFS]?

“I am a champion woman of the UFS; I embrace my uniqueness, and I strive for academic excellence and to empower others through research and innovation. I say no to discrimination, no to gender-based violence, and no to gender inequality. I am generation equality, and this is my legacy.”

 

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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