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Prof Anthony Turton from the Centre for Environmental Management at the University of the Free State (UFS).

Since a South African team associated with the University of the Free State (UFS) became the first to isolate the SARS-CoV-2 virus from wastewater and developed a viable virus risk forensic service, there has been interest in this technology from a range of role players in North America, Africa, the Middle East, and Southeast Asia, to the South African government.

Prof Anthony Turton from the Centre for Environmental Management at the UFS says contact has been made with two separate scientific teams working in South Africa – one in the Western Cape associated with the Department of Health, and one coordinated by the Water Research Commission reporting to the Department of Water and Sanitation (DWS) – both of which are developing next-generation science. 

Prof Turton says the team has also presented a formal report to the DWS to show that first-generation science is quite capable of generating accurate data that is of great value to planners by feeding into national decision-making bodies.  

A proud achievement 
“As the person who conceptualised this service, I am very proud to be a South African citizen. My background is in national security, so it was that skill set which I applied to the problem when I asked the question – how can we provide the best available information in the shortest possible time, in the face of high risk and growing uncertainty, using the best available technology? This is only possible when one is trained in the intelligence sciences. Intelligence is about converting raw data, often from contested sources, into actionable bits of information with a defined level of certainty.” 
“However, the truly remarkable portion is the team that we rapidly assembled. By hand-picking the right kind of people for the team, we could unlock the power of synergy where 1 + 1 becomes 3. We, as South Africans, have developed a world first, and this is something we can collectively be deeply proud of. This is a proudly South African achievement, not an individual achievement. The benefits belong to society, because even when I was at the CSIR, I championed the notion of ‘science in the service of society’, and here we have another example,” says Prof Turton.

Using available technology
With the 824 wastewater treatment works (WWTW) in the country, the DWS can rapidly deploy this technology to any existing area of concern if they see value in it.  “At present, government is waiting for second-generation science to become available, but that is probably 24 months away at best. In the interim, a crisis is unfolding in the present, and first-generation science is clearly capable of providing sufficiently accurate information to assist in decision-making around the deployment of increasingly scarce resources.”

“DWS used similar technology in the cholera crisis a while back, so they are aware of the benefits. From a society perspective, the question is whether government must wait for the second-generation science to emerge before using the technology, even though first-generation technology can provide an important part of the missing data as explained above. This is what the foreign entities have grasped.”

According to Prof Turton, the interest shown in this technology is from both government and the private sector in North America, Africa, the Middle East, and Southeast Asia. A number of key decision-makers see the value of this technology in mitigating both financial and political risk. 

“They recognise that this pandemic is here to stay for a while, so they intend to get ahead of the curve, which is what the forensics service allows. An example is a condominium where a few hundred people live, but who are unable to use the facilities that they pay levies for. This service will enable all residents in a specific condominium to rebuild trust that they live in a ‘safe space’.” 

“For government, they recognise that this technology can feed data into their mapping systems. They refer to a ‘heat map’ that shows areas of viral activity and areas of relative safety. In one case, the focus is on monitoring each building in a city to identify which building is safe and which is a hot spot,” says Prof Turton. 

Next-generation science 
He explains that next-generation science refers to the algorithms used to extrapolate viral-load data to a larger cohort of people. The first-generation science was about the detection of the virus as a binary measurement: “Is the virus present, yes or no?”

“The current science can do this without a problem. Second-generation science is about how much virus is present? Is this more, or less, than we saw last week? If so, how much bigger or smaller is the signal? If so, can we mathematically calculate from a defined quantum of signal an accurate probability of the total viral load in the population being sampled?” 

“From this, can we say that 15% of the population is shedding virus (a number currently only possible from sewage surveillance) but personal testing shows us that only 5% of the population is positive? If so, we can then say that 10% of the population is both positive and asymptomatic. This has major implications for decision-makers, business owners, tourism operators, and governments who are losing revenue because of failing economies.” 
More importantly, says Prof Turton, is that this missing piece of data will become vital in testing for herd immunity, or the efficacy of a vaccine once available. 

The cost of the service 
By presenting a formal report to DWS, the team was able to get an accurate costing of the service. The cost of a single sewage sample, which can accurately monitor a geographically defined cohort (let’s say 100 000 people for the sake of illustration), is equivalent to 15–20 individual samples (nasal swabs, for example). “We can sample 100 000 people at the same cost as 15 can be sampled individually. More importantly, it is highly unlikely that any government in the world will ever reach anything more than 10% sampling at individual level. This tells us that while individual sampling might be very useful, it is logistically complex, and has a political risk when it cannot be rolled out across a large enough portion of society,” says Prof Turton.  

“The virus-risk forensic service that we have been developing can identify specific hot-spot areas, and those can be targeted for higher saturation coverage of individual testing. For example, in the DWS PoC, we identified one specific WWTW that is a definite hot spot, but another that has no viral signal at all. This means that those people living in the area with no viral signal are safe and do not need to be individually tested, but those in the hot spot need to be isolated and targeted for individual testing. More importantly, we can now say that the hot-spot area is likely to result in demand for medical services in a specific area, so planning can be done before the wave hits the hospital,” explains Prof Turton.   
With the submission of the formal report to government, the Business Water Chamber, and the Public Private Growth Initiative (PPGI), we can now announce a team to offer this virus-risk forensic service to any party with a need for this support in both the public and private sectors.

The team is:  
• Prof Anthony Turton – Centre for Environmental Management at the UFS, responsible for the conceptual design of the virus-risk forensic service. 

• Dr Mpafane Deyi – a graduate from the UFS and CEO of Amanzi-4-All, responsible for implementation of the service to both private and public sector partners.

• Dr Leon Geustyn – Director of Amanzi-4-All, responsible for the mathematical and technical aspects of the risk-based diagnostic service. 

• Dr Shaun Groenink – Director of GreenHill Laboratories, responsible for the laboratory support required.
• Dr Cara-Lesley Bartlett – Senior Scientist at GreenHill Laboratories.

• Mr Neil Madgwick – Director of Praecautio, responsible for the coordination of laboratories as the service grows across the African continent.

• Mr Kevin Lindsay – Director of Instru-Serve, responsible for the refinement of bulk sampling techniques and the supply chain from point of collection to the laboratories.
 

News Archive

Gender bias still rife in African Universities
2007-08-03

 

 At the lecture were, from the left: Prof. Magda Fourie (Vice-Rector: Academic Planning), Prof. Amina Mama (Chair: Gender Studies, University of Cape Town), Prof. Engela Pretorius (Vice-Dean: Humanties) and Prof. Letticia Moja (Dean: Faculty of Health Sciences).
Photo: Stephen Collett

Gender bias still rife in African Universities

Women constitute about 30% of student enrolment in African universities, and only about 6% of African professors are women. This is according to the chairperson of Gender Studies at the University of Cape Town, Prof Amina Mama.

Prof Mama was delivering a lecture on the topic “Rethinking African Universities” as part of Women’s Day celebrations at the University of the Free State (UFS) today.

She says the gender profile suggests that the majority of the women who work in African universities are not academics and researchers, but rather the providers of secretarial, cleaning, catering, student welfare and other administrative and support services.

She said that African universities continue to display profound gender bias in their students and staffing profiles and, more significantly, are deeply inequitable in their institutional and intellectual cultures. She said women find it difficult to succeed at universities as they are imbued with patriarchal values and assumptions that affect all aspects of life and learning.

She said that even though African universities have never excluded women, enrolling them presents only the first hurdle in a much longer process.

“The research evidence suggests that once women have found their way into the universities, then gender differentiations continue to arise and to affect the experience and performance of women students in numerous ways. Even within single institutions disparities manifest across the levels of the hierarchy, within and across faculties and disciplines, within and between academic and administrative roles, across generations, and vary with class and social background, marital status, parental status, and probably many more factors besides these”, she said.

She lamented the fact that there is no field of study free of gender inequalities, particularly at postgraduate levels and in the higher ranks of academics. “Although more women study the arts, social sciences and humanities, few make it to professor and their research and creative output remains less”, she said.

Prof Mama said gender gaps as far as employment of women within African universities is concerned are generally wider than in student enrolment. She said although many women are employed in junior administrative and support capacities, there continues to be gross under-representation of women among senior administrative and academic staff. She said this disparity becomes more pronounced as one moves up the ranks.

“South African universities are ahead, but they are not as radically different as their policy rhetoric might suggest. A decade and a half after the end of apartheid only three of the 23 vice-chancellors in the country are women, and women fill fewer than 30% of the senior positions (Deans, Executive Directors and Deputy Vice-Chancellors)”, she said.

She made an observation that highly qualified women accept administrative positions as opposed to academic work, thus ensuring that men continue to dominate the ranks of those defined as ‘great thinkers’ or ‘accomplished researchers’.

“Perhaps women simply make realistic career choices, opting out of academic competition with male colleagues who they can easily perceive to be systematically advantaged, not only within the institution, but also on the personal and domestic fronts, which still see most African women holding the baby, literally and figuratively”, she said

She also touched on sexual harassment and abuse which she said appears to be a commonplace on African campuses. “In contexts where sexual transactions are a pervasive feature of academic life, women who do succeed are unlikely to be perceived as having done so on the basis of merit or hard work, and may be treated with derision and disbelief”, she said.

She, however, said in spite of broader patterns of gender and class inequality in universities, public higher education remains a main route to career advancement and mobility for women in Africa.

“Women’s constrained access has therefore posed a constraint to their pursuit of more equitable and just modes of political, economic and social development, not to mention freedom from direct oppression”, she said.

Prof Mama concluded by saying, “There is a widely held agreement that there is a need to rethink our universities and to ensure that they are transformed into institutions more compatible with the democratic and social justice agendas that are now leading Africa beyond the legacies of dictatorship, conflict and economic crisis, beyond the deep social divisions and inequalities that have characterised our history”.

She said rethinking universities means asking deeper questions about gender relations within them, and taking concerted and effective action to transform these privileged bastions of higher learning so that they can fulfil their pubic mandate and promise instead of lagging behind our steadily improving laws and policies.

Media Release
Issued by: Mangaliso Radebe
Assistant Director: Media Liaison
Tel: 051 401 2828
Cell: 078 460 3320
E-mail: radebemt.stg@ufs.ac.za  
02 August 2007
 

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