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26 May 2020 | Story Marcus Maphile | Photo Supplied
Marcus Maphile
The African continent is known for endless wars, extreme poverty, under-development, and highly contested borders left by the legacy of colonialism. Low levels of literacy among young people and adults remain a concern in many African states. African universities are slowly beginning to play a significant role in contributing to national innovation systems that seek to change the socio-economic and other fortunes of many poor and marginalised Africans. 

The African continent celebrates the 57th anniversary of the founding of the Organisation of African Unity (OAU), and the relevance of the current African Union (AU) in the fight against socio-economic challenges caused by COVID-19 on the continent. The fear faced by most African countries emanates from inadequate healthcare systems and facilities. The debate on the opening of schools and institutions of higher learning is passed around like a soccer ball, as countries are aware that they lack the capacity to accommodate a surge of COVID-19 infections.

The African higher education and research sector is struggling to adapt. Will they be able to play a significant role towards finding a vaccine, producing new knowledge or research from African indigenous plants?  To be factual, in many ways this is not likely to happen, as most of the higher education institutions struggle with internet connectivity and high data costs. Many books and journals in libraries remain inaccessible, and most will only later record how developed countries moved to online teaching and learning with great success or failure.   All this will happen under the noses of illiterate Africans who rightly expect their higher education and research institutions to contribute towards finding immediate responses to the COVID-19 pandemic threat.

Most public and academic libraries remain closed and there is no word and contribution from highly decorated professionals towards sustaining reading habits and availing relevant materials for research towards finding a vaccine. There is no co-ordinated plan from library ministries and or library lobby groups. This is the context in which Africa Month 2020 is celebrated. It will be remembered as the year in which the promotion of reading and the opening of schools took a beating.

Marcus Maphile is Assistant Director: Library Marketing at the University of the Free State and he writes in his personal capacity.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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