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08 September 2020 | Story Leonie Bolleurs | Photo Falko Buschke
Dr Falko Buschke says the iconic sandstone cliffs of the eastern Free State are key to protecting wild plants and animals from climate change.

The iconic sandstone cliffs of the eastern Free State are often the focus of paintings and postcards. Now, new research shows they also protect wild plants and animals from climate change. This finding is the outcome of a collaborative research effort by the University of the Free State (UFS); BirdLife South Africa; the Vrije Universiteit Brussel and KU Leuven, Belgium, which has recently been published in the journal Biological Conservation.

Mountains key for climate change mitigation

The study, led by Dr Falko Buschke from the Centre for Environmental Management UFS, used satellite data from NASA to track the ecological effects of wet and dry seasons, including the record drought of 2015/16. This showed how vegetation on the cool and moist mountain slopes was less affected by dry spells.

The complex physical terrain allows moisture to accumulate in the shaded parts of the south-facing slopes and ravines. This creates cool and moist habitats for plants and animals that wouldn’t survive in the rest of the hotter and drier landscape.

The team also discovered that these positive effects of mountains do not end at the foot of the mountain, but extend at least 500m into the flatter lowlands. “Presumably because water and nutrients accumulate in these surrounding buffers due to run-off,” says Dr Buschke.

Butterflies find safety on mountains

In addition to their high-tech analysis of the area, the team also relied on old-fashioned fieldwork to monitor butterflies over two years. “The data showed us how these insects find safety on mountains during harsh climate conditions and can then recolonise the rest of the landscape after conditions improve,” explains Dr Buschke. “This gives us clues on the best way to protect nature,” he adds. 

This study took place in the Rooiberge-Riemland Key Biodiversity Area (KBA), an area significant for maintaining global biodiversity. Several species of insects, reptiles, birds and mammals here occur nowhere else on earth. “If they disappear here, they will go extinct from the whole planet forever,” says Dr Falko Buschke. 

Despite its ecological significance, most of the area is covered by commercial farmland. So, the next stage of the project is exploring ways of protecting these important habitats while ensuring that farmers can continue producing food and supporting rural livelihoods. 

Farmers hold the key to preserving biodiversity,” says Dr Buschke, “so conservation scientists need to work closely with them to ensure that we protect species for future generations.” 

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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