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28 September 2020 | Story Andre Damons | Photo Supplied
Dr Martin Nyaga, Senior Lecturer and Researcher: NGS, will be heading the World Health Organisation Collaborating Centre (WHO CC).

The University of the Free State (UFS) has been designated a World Health Organisation Collaborating Centre (WHO CC), and the university’s Next Generation Sequencing (NGS) Unit, in partnership with the World Health Organisation (WHO), will for the next four years be conducting genome sequencing of pathogenic organisms, including rotavirus strains from the African continent. 

This centre will be part of the Vaccine Preventable Diseases (VPD) Pathogens Genomics Cluster and will run from September 2020 to September 2024. 

Dr Martin Nyaga, Senior Lecturer and Researcher: NGS/Virology, who will be heading the WHO CC, says an institution is designated as a WHO CC by the WHO Director-General and endorsed by the host country’s minister of health to form part of an international collaborative network, carrying out activities in support of the WHO programmess at all levels. A designation as a WHO CC is a time-limited agreement of collaboration between WHO and the designated institution, through which the latter agrees to implement a series of concrete activities, specifically designed for WHO.

A supreme achievement

Says Dr Nyaga: “In my opinion, a WHO CC designation is one of the supreme achievements an institution can be conferred as a recognition for foregoing exceptional collaborative venture with the WHO and showing future potential to assist the WHO with its global programmes and in our case, the WHO Regional Office for Africa region to offer solutions to the WHO VPD Surveillance and pathogens genomics cluster.”

According to Dr Nyaga this designation was awarded to the UFS after the WHO was content with the outcome of a service contract whereby the UFS-NGS unit undertook a pilot rotavirus surveillance project at whole genome level, using two African countries for the pilot, Rwanda and Zambia.

“From the outcomes of the pilot surveillance project between 2017 and 2019, the WHO/AFRO was satisfied with the genomic data that was generated and partially disseminated in scientific databases and journals as a collaborative venture. 

“It was thus proposed to strengthen its existing collaboration with the UFS-NGS Unit, which initiated the application process to designate the UFS-NGS unit as a WHO CC, an initiative that has taken approximately 20 months to finalise through the different phases of the application and approvals for the designation,” explains Dr Nyaga.

The purpose of the WHO CC

The new WHO CC will upon request by the WHO, implement agreed work plans in a timely manner and to the highest possible standards of quality and must comply with the referred terms of reference and conditions. These include: 
• Conducting genome sequencing of pathogenic organisms causing VPD, including rotavirus strains collected as part of the routine VPD surveillance using NGS technology and analysis of the generated datasets using bioinformatics tools.

• Conducting molecular characterisation of specimens collected during outbreaks and public health emergencies as part of the support for monitoring, preparedness and response to VPD disease outbreaks in Africa.

• Provide technical guidance to WHO on strategies to improve laboratory molecular diagnostics, molecular typing and NGS of rotavirus diarrheal strains and other enteropathogens to detect novel and re-emerging strains. 

• Conduct validation of tools and new molecular diagnostics for detection and characterisation of unusual or rare VPD strains to guide studies and development of new vaccines for VPD.

• Organise capacity-building and training workshops on whole genome sequencing of priority VPD pathogenic organisms.

The impact of the WHO CC on the work of the UFS-NGS 

According to Dr Nyaga, the designation brings extra responsibilities to his work and to the activities of the UFS-NGS unit. “Such initiatives are very welcome to enhance the business aspects, research and academic activities of the UFS-NGS unit, as the benefits are quite holistic since the collaboration enhances co-ownership of data and offers opportunities to train postgraduate students and other scientists.

“It also expands the research infrastructure and most importantly contributes to policy for numerous African governments in important decisions such as vaccine implementation activities, from an informed point of view and managing public health needs that require rapid response like outbreaks that may lead to pandemics.” 
• The current WHO CC designations at South African Institutions of higher learning and research can be found at: 

News Archive

Africa the birthplace of mathematics, says Prof Atangana
2017-11-17


 Description: Prof Abdon Atangana, African Award of Applied Mathematics  Tags: Prof Abdon Atangana, African Award of Applied Mathematics

Prof Abdon Atangana from the UFS Institute for Groundwater Studies.
Photo: Supplied

 

Prof Abdon Atangana from the Institute for Groundwater Studies at the University of the Free State recently received the African Award of Applied Mathematics during the International conference "African’s Days of Applied Mathematics" that was held in Errachidia, Morocco. Prof Atangana delivered the opening speech with the title "Africa was a temple of knowledge before: What happened?” The focus of the conference was to offer a forum for the promotion of mathematics and its applications in African countries.

When Europeans first came to Africa, they considered the architecture to be disorganised and thus primitive. It never occurred to them that Africans might have been using a form of mathematics that they hadn’t even discovered yet.

Africa is home to the world’s earliest known use of measuring and calculation. Thousands of years ago Africans were using numerals, algebra and geometry in daily life. “Our continent is the birthplace of both basic and advanced mathematics,” said Prof Atangana. 

Africa attracted a series of immigrants who spread knowledge from this continent to the rest of the world.

Measuring and counting
In one of his examples of African mathematics knowledge Prof Atangana referred to the oldest mathematical instrument as the Lebombo bone, a baboon fibula used as a measuring instrument, which was named after the Lebombo Mountains of Swaziland. The world’s oldest evidence of advanced mathematics was also a baboon fibula that was discovered in present-day Democratic Republic of Congo.

Another example he used is the manuscripts in the libraries of the Sankoré University, one of the world’s oldest tertiary institutions. This university in Timbuktu, Mali, is full of manuscripts mainly written in Ajami in the 1200s AD. “When Europeans and Western Asians began visiting and colonising Mali between the 1300s and 1800s, Malians hid the manuscripts in basements, attics and underground, fearing destruction or theft by foreigners. This was certainly a good idea, given the Europeans' history of destroying texts in Kemet and other areas of the continent. Many of the scripts were mathematical and astronomical in nature. In recent years, as many as 700 000 scripts have been rediscovered and attest to the continuous knowledge of advanced mathematics and science in Africa well before European colonisation. 

Fractal geometry

“One of Africa’s major achievements was the advanced knowledge of fractal geometry. This knowledge is found in a wide aspect of Africa life: from art, social design structures, architecture, to games, trade and divination systems. 

“The binary numeral system was also widely known through Africa before it was known throughout much of the world. There is a theory that it could have influenced Western geometry, which led to the development of digital computers,” he said. 

“Can Africa rise again?” Prof Atangana believes it can.

He concluded with a plea to fellow African researchers to do research that will build towards a new Africa.

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