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28 September 2020 | Story Andre Damons | Photo Supplied
Dr Martin Nyaga, Senior Lecturer and Researcher: NGS, will be heading the World Health Organisation Collaborating Centre (WHO CC).
The University of the Free State (UFS) has been designated a World Health Organisation Collaborating Centre (WHO CC), and the university’s Next Generation Sequencing (NGS) Unit, in partnership with the World Health Organisation (WHO), will for the next four years be conducting genome sequencing of pathogenic organisms, including rotavirus strains from the African continent. 

This centre will be part of the Vaccine Preventable Diseases (VPD) Pathogens Genomics Cluster and will run from September 2020 to September 2024. 

Dr Martin Nyaga, Senior Lecturer and Researcher: NGS/Virology, who will be heading the WHO CC, says an institution is designated as a WHO CC by the WHO Director-General and endorsed by the host country’s minister of health to form part of an international collaborative network, carrying out activities in support of the WHO programmess at all levels. A designation as a WHO CC is a time-limited agreement of collaboration between WHO and the designated institution, through which the latter agrees to implement a series of concrete activities, specifically designed for WHO.

A supreme achievement

Says Dr Nyaga: “In my opinion, a WHO CC designation is one of the supreme achievements an institution can be conferred as a recognition for foregoing exceptional collaborative venture with the WHO and showing future potential to assist the WHO with its global programmes and in our case, the WHO Regional Office for Africa region to offer solutions to the WHO VPD Surveillance and pathogens genomics cluster.”

According to Dr Nyaga this designation was awarded to the UFS after the WHO was content with the outcome of a service contract whereby the UFS-NGS unit undertook a pilot rotavirus surveillance project at whole genome level, using two African countries for the pilot, Rwanda and Zambia.

“From the outcomes of the pilot surveillance project between 2017 and 2019, the WHO/AFRO was satisfied with the genomic data that was generated and partially disseminated in scientific databases and journals as a collaborative venture. 

“It was thus proposed to strengthen its existing collaboration with the UFS-NGS Unit, which initiated the application process to designate the UFS-NGS unit as a WHO CC, an initiative that has taken approximately 20 months to finalise through the different phases of the application and approvals for the designation,” explains Dr Nyaga.

The purpose of the WHO CC

The new WHO CC will upon request by the WHO, implement agreed work plans in a timely manner and to the highest possible standards of quality and must comply with the referred terms of reference and conditions. These include: 
• Conducting genome sequencing of pathogenic organisms causing VPD, including rotavirus strains collected as part of the routine VPD surveillance using NGS technology and analysis of the generated datasets using bioinformatics tools.

• Conducting molecular characterisation of specimens collected during outbreaks and public health emergencies as part of the support for monitoring, preparedness and response to VPD disease outbreaks in Africa.

• Provide technical guidance to WHO on strategies to improve laboratory molecular diagnostics, molecular typing and NGS of rotavirus diarrheal strains and other enteropathogens to detect novel and re-emerging strains. 

• Conduct validation of tools and new molecular diagnostics for detection and characterisation of unusual or rare VPD strains to guide studies and development of new vaccines for VPD.

• Organise capacity-building and training workshops on whole genome sequencing of priority VPD pathogenic organisms.

The impact of the WHO CC on the work of the UFS-NGS 

According to Dr Nyaga, the designation brings extra responsibilities to his work and to the activities of the UFS-NGS unit. “Such initiatives are very welcome to enhance the business aspects, research and academic activities of the UFS-NGS unit, as the benefits are quite holistic since the collaboration enhances co-ownership of data and offers opportunities to train postgraduate students and other scientists.

“It also expands the research infrastructure and most importantly contributes to policy for numerous African governments in important decisions such as vaccine implementation activities, from an informed point of view and managing public health needs that require rapid response like outbreaks that may lead to pandemics.” 
• The current WHO CC designations at South African Institutions of higher learning and research can be found at: 

News Archive

School of Medicine expands to provide quality tuition
2015-04-20

 

The School of Medicine at the University of the Free State (UFS) has recently extended various training platforms to provide continuous quality tuition to students.

Not only does the school boast a world-class dissection hall but now has plans for additional training facilities at two more hospitals.

The new dissection hall was completed in January 2015 with some final finishing touches that will be done shortly. The hall is newly built as the previous dissection hall has been used for undergraduate anatomy training since 1972.

Dr Sanet van Zyl, Senior Lecturer in the Department of Basic Medical Science, says owing to a prospective growth in the number of medical students as well as changing methods in teaching and learning, the need for a new dissection hall became evident to ensure that students get an optimal learning experience during dissection tuition.

“The new spacious dissection hall is equipped with special lighting and modern equipment for the training programme for second-year medical students. The hall is further equipped with modern sound and computer equipment. A unique camera system will allow students to follow dissection demonstrations on ten screens in the hall. Dissection demonstrations can also be recorded, enabling lecturers to put together new materials for teaching and learning.”

In addition to anatomy teaching for under- and postgraduate medical students, the Department of Basic Medical Science also offers anatomy teaching to under-graduate students from the School of Nursing, the School of Allied Health Professions as well as students from the Natural and Agricultural Sciences (such as students studying Forensic Science). The old dissection hall will still be used for the anatomy training of these students.

“The dissection programme for medical students is of critical importance, not only to acquire anatomical knowledge, but also for the development of critical skills and professionalism of our students. As already mentioned, these modern facilities will enable us to be at the forefront of current development in this field. This will benefit both present and future generations of medical students.”

At the same time, Prof Alan St. Clair Gibson, Head of the School of Medicine, announced that lecturing facilities are being developed at the Kimberley Hospital Complex. There are also plans for study facilities at the UFS’s Qwaqwa Campus and Bongani Hospital in Welkom. The UFS’s planning is also well underway for lecturing and residential facilities for students in Trompsburg, where students will receive training at the Trompsburg Hospital.

“We are very privileged to have these facilities and they will help us to provide world class training for students in the School of Medicine,” Prof St. Clair Gibson says.

 

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