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28 September 2020 | Story Andre Damons | Photo Supplied
Dr Martin Nyaga, Senior Lecturer and Researcher: NGS, will be heading the World Health Organisation Collaborating Centre (WHO CC).
The University of the Free State (UFS) has been designated a World Health Organisation Collaborating Centre (WHO CC), and the university’s Next Generation Sequencing (NGS) Unit, in partnership with the World Health Organisation (WHO), will for the next four years be conducting genome sequencing of pathogenic organisms, including rotavirus strains from the African continent. 

This centre will be part of the Vaccine Preventable Diseases (VPD) Pathogens Genomics Cluster and will run from September 2020 to September 2024. 

Dr Martin Nyaga, Senior Lecturer and Researcher: NGS/Virology, who will be heading the WHO CC, says an institution is designated as a WHO CC by the WHO Director-General and endorsed by the host country’s minister of health to form part of an international collaborative network, carrying out activities in support of the WHO programmess at all levels. A designation as a WHO CC is a time-limited agreement of collaboration between WHO and the designated institution, through which the latter agrees to implement a series of concrete activities, specifically designed for WHO.

A supreme achievement

Says Dr Nyaga: “In my opinion, a WHO CC designation is one of the supreme achievements an institution can be conferred as a recognition for foregoing exceptional collaborative venture with the WHO and showing future potential to assist the WHO with its global programmes and in our case, the WHO Regional Office for Africa region to offer solutions to the WHO VPD Surveillance and pathogens genomics cluster.”

According to Dr Nyaga this designation was awarded to the UFS after the WHO was content with the outcome of a service contract whereby the UFS-NGS unit undertook a pilot rotavirus surveillance project at whole genome level, using two African countries for the pilot, Rwanda and Zambia.

“From the outcomes of the pilot surveillance project between 2017 and 2019, the WHO/AFRO was satisfied with the genomic data that was generated and partially disseminated in scientific databases and journals as a collaborative venture. 

“It was thus proposed to strengthen its existing collaboration with the UFS-NGS Unit, which initiated the application process to designate the UFS-NGS unit as a WHO CC, an initiative that has taken approximately 20 months to finalise through the different phases of the application and approvals for the designation,” explains Dr Nyaga.

The purpose of the WHO CC

The new WHO CC will upon request by the WHO, implement agreed work plans in a timely manner and to the highest possible standards of quality and must comply with the referred terms of reference and conditions. These include: 
• Conducting genome sequencing of pathogenic organisms causing VPD, including rotavirus strains collected as part of the routine VPD surveillance using NGS technology and analysis of the generated datasets using bioinformatics tools.

• Conducting molecular characterisation of specimens collected during outbreaks and public health emergencies as part of the support for monitoring, preparedness and response to VPD disease outbreaks in Africa.

• Provide technical guidance to WHO on strategies to improve laboratory molecular diagnostics, molecular typing and NGS of rotavirus diarrheal strains and other enteropathogens to detect novel and re-emerging strains. 

• Conduct validation of tools and new molecular diagnostics for detection and characterisation of unusual or rare VPD strains to guide studies and development of new vaccines for VPD.

• Organise capacity-building and training workshops on whole genome sequencing of priority VPD pathogenic organisms.

The impact of the WHO CC on the work of the UFS-NGS 

According to Dr Nyaga, the designation brings extra responsibilities to his work and to the activities of the UFS-NGS unit. “Such initiatives are very welcome to enhance the business aspects, research and academic activities of the UFS-NGS unit, as the benefits are quite holistic since the collaboration enhances co-ownership of data and offers opportunities to train postgraduate students and other scientists.

“It also expands the research infrastructure and most importantly contributes to policy for numerous African governments in important decisions such as vaccine implementation activities, from an informed point of view and managing public health needs that require rapid response like outbreaks that may lead to pandemics.” 
• The current WHO CC designations at South African Institutions of higher learning and research can be found at: 

News Archive

Two research chairs awarded to UFS women
2015-09-15


Prof Pumla Gobodo-Madikizela

Two professors at the University of the Free State (UFS) have just been chosen as recipients of research chairs by the National Research Foundation’s South African Research Chair Initiative.

The research chairs are a massive financial injection for research in each of the relevant disciplines – that of Profs Pumla Gobodo-Madikizela from the Centre for Trauma, Forgiveness, and Reconciliation Studies at the UFS, and Felicity Burt from the Department of Medical Microbiology in the Faculty of Health Sciences.

Profs Gobodo-Madikizela and Burt are two of 42 female researchers in the country receiving research chairs as an initiative to give due recognition to women in research.

Profs Hendrik Swart, from our Departement of Physics and Melany Walker, Director, Centre for Research on Higher Education and Development, each also holds research chairs by the NRF. A third research chair has also been granted to the UFS Department of Plant Sciences for the research in field crops.


Prof Felicity Burt

The work of Prof Burt’s research chair is to investigate medically significant vector-borne and zoonotic viruses currently circulating; to define associations between these viruses and specific disease manifestations that have previously not been described in our region, to increase awareness of these pathogens; to further our understanding of host immune responses, which should facilitate development of novel treatments or vaccines and drug discovery.

Prof Gobodo-Madikizela, who has received international recognition for her work on forgiveness studies, will use this research chair to investigate historical trauma within two African contexts – those of South Africa and Rwanda. She hopes to gain insight into the role that memory plays in the formation of the experience of trauma, and to bring about healing of the trauma.

Prof Corli Witthuhn, Vice-Rector: Research at the UFS, expressed her pride on the announcement.

“We are extremely proud of the national recognition these two outstanding women researchers received.  The UFS strives for research excellence, and the five current NRF research chairs, as well as two NRF A-graded researchers who are at the forefront of their disciplines globally, indicates our continued commitment to innovating, relevant, and high-impact research.  We are excited about the progress of the past two years to position the UFS as a national leader in research.”

 

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