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28 September 2020 | Story Andre Damons | Photo Supplied
Dr Martin Nyaga, Senior Lecturer and Researcher: NGS, will be heading the World Health Organisation Collaborating Centre (WHO CC).

The University of the Free State (UFS) has been designated a World Health Organisation Collaborating Centre (WHO CC), and the university’s Next Generation Sequencing (NGS) Unit, in partnership with the World Health Organisation (WHO), will for the next four years be conducting genome sequencing of pathogenic organisms, including rotavirus strains from the African continent. 

This centre will be part of the Vaccine Preventable Diseases (VPD) Pathogens Genomics Cluster and will run from September 2020 to September 2024. 

Dr Martin Nyaga, Senior Lecturer and Researcher: NGS/Virology, who will be heading the WHO CC, says an institution is designated as a WHO CC by the WHO Director-General and endorsed by the host country’s minister of health to form part of an international collaborative network, carrying out activities in support of the WHO programmess at all levels. A designation as a WHO CC is a time-limited agreement of collaboration between WHO and the designated institution, through which the latter agrees to implement a series of concrete activities, specifically designed for WHO.

A supreme achievement

Says Dr Nyaga: “In my opinion, a WHO CC designation is one of the supreme achievements an institution can be conferred as a recognition for foregoing exceptional collaborative venture with the WHO and showing future potential to assist the WHO with its global programmes and in our case, the WHO Regional Office for Africa region to offer solutions to the WHO VPD Surveillance and pathogens genomics cluster.”

According to Dr Nyaga this designation was awarded to the UFS after the WHO was content with the outcome of a service contract whereby the UFS-NGS unit undertook a pilot rotavirus surveillance project at whole genome level, using two African countries for the pilot, Rwanda and Zambia.

“From the outcomes of the pilot surveillance project between 2017 and 2019, the WHO/AFRO was satisfied with the genomic data that was generated and partially disseminated in scientific databases and journals as a collaborative venture. 

“It was thus proposed to strengthen its existing collaboration with the UFS-NGS Unit, which initiated the application process to designate the UFS-NGS unit as a WHO CC, an initiative that has taken approximately 20 months to finalise through the different phases of the application and approvals for the designation,” explains Dr Nyaga.

The purpose of the WHO CC

The new WHO CC will upon request by the WHO, implement agreed work plans in a timely manner and to the highest possible standards of quality and must comply with the referred terms of reference and conditions. These include: 
• Conducting genome sequencing of pathogenic organisms causing VPD, including rotavirus strains collected as part of the routine VPD surveillance using NGS technology and analysis of the generated datasets using bioinformatics tools.

• Conducting molecular characterisation of specimens collected during outbreaks and public health emergencies as part of the support for monitoring, preparedness and response to VPD disease outbreaks in Africa.

• Provide technical guidance to WHO on strategies to improve laboratory molecular diagnostics, molecular typing and NGS of rotavirus diarrheal strains and other enteropathogens to detect novel and re-emerging strains. 

• Conduct validation of tools and new molecular diagnostics for detection and characterisation of unusual or rare VPD strains to guide studies and development of new vaccines for VPD.

• Organise capacity-building and training workshops on whole genome sequencing of priority VPD pathogenic organisms.

The impact of the WHO CC on the work of the UFS-NGS 

According to Dr Nyaga, the designation brings extra responsibilities to his work and to the activities of the UFS-NGS unit. “Such initiatives are very welcome to enhance the business aspects, research and academic activities of the UFS-NGS unit, as the benefits are quite holistic since the collaboration enhances co-ownership of data and offers opportunities to train postgraduate students and other scientists.

“It also expands the research infrastructure and most importantly contributes to policy for numerous African governments in important decisions such as vaccine implementation activities, from an informed point of view and managing public health needs that require rapid response like outbreaks that may lead to pandemics.” 
• The current WHO CC designations at South African Institutions of higher learning and research can be found at: 

News Archive

Vishuis’s fourth Varsity Cup victory about more than rugby
2016-04-15

Description: Vishuis Tags: Vishuis

House Abraham Fischer, a residence from the University of the Free State, is the most successful team in the history of the Varsity Cup. Vishuis beat Patria (Pukke) in the 2016 final of the tournament.
Photo: SASPA
 

For Vishuis, it is about more than just rugby.

This is what Henco Posthumus, captain of House Abraham Fischer’s rugby team, had to say after his team was crowned the national Varsity Cup champions for an incredible fourth time. According to the flyhalf, the title of the leading residence team in the country is “special for the guys”.

Vishuis is the most successful residence team in the history of the tournament. Apart from their four titles, they have played in a total of five Varsity Cup finals.

On 11 April 2016, the residence from the University of the Free State (UFS) launched a great comeback in Stellenbosch to beat Patria (Pukke) by 37-29. This victory ensured that Vishuis was unbeaten in 2016.

Great fighting spirit


The Kovsies started off well against Patria, but were behind 16-29 shortly after break, and had to “delve deep”, according to Posthumus. “To be behind in this way is not what one would prefer. For some reason, we have been in similar situations before, and we know how to make a comeback,” he said.

“We looked one another in the eye and decided that we are not going to lose again in the final.” In last year’s final in Bloemfontein, when Posthumus played at fullback, Vishuis got stuck against Mopanie (Tuks) at the end of the match, and they wanted to prevent this from happening again.

Heymans a hero


According to the Vishuis captain, one of his team’s assistant coaches, Franco (Vaatjie) van der Merwe, spoke harshly to the players when they were behind. The victory was clinched in the dying moments, with the second try of scrumhalf, Ruben Heymans, when the score was 29 points each. Heymans was a star, and the well-deserved Man of the Match.

Posthumus said it is a great privilege to carry the title of Varsity Cup champions. His team has worked hard to reach the top.

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