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28 September 2020 | Story Andre Damons | Photo Supplied
Dr Martin Nyaga, Senior Lecturer and Researcher: NGS, will be heading the World Health Organisation Collaborating Centre (WHO CC).
The University of the Free State (UFS) has been designated a World Health Organisation Collaborating Centre (WHO CC), and the university’s Next Generation Sequencing (NGS) Unit, in partnership with the World Health Organisation (WHO), will for the next four years be conducting genome sequencing of pathogenic organisms, including rotavirus strains from the African continent. 

This centre will be part of the Vaccine Preventable Diseases (VPD) Pathogens Genomics Cluster and will run from September 2020 to September 2024. 

Dr Martin Nyaga, Senior Lecturer and Researcher: NGS/Virology, who will be heading the WHO CC, says an institution is designated as a WHO CC by the WHO Director-General and endorsed by the host country’s minister of health to form part of an international collaborative network, carrying out activities in support of the WHO programmess at all levels. A designation as a WHO CC is a time-limited agreement of collaboration between WHO and the designated institution, through which the latter agrees to implement a series of concrete activities, specifically designed for WHO.

A supreme achievement

Says Dr Nyaga: “In my opinion, a WHO CC designation is one of the supreme achievements an institution can be conferred as a recognition for foregoing exceptional collaborative venture with the WHO and showing future potential to assist the WHO with its global programmes and in our case, the WHO Regional Office for Africa region to offer solutions to the WHO VPD Surveillance and pathogens genomics cluster.”

According to Dr Nyaga this designation was awarded to the UFS after the WHO was content with the outcome of a service contract whereby the UFS-NGS unit undertook a pilot rotavirus surveillance project at whole genome level, using two African countries for the pilot, Rwanda and Zambia.

“From the outcomes of the pilot surveillance project between 2017 and 2019, the WHO/AFRO was satisfied with the genomic data that was generated and partially disseminated in scientific databases and journals as a collaborative venture. 

“It was thus proposed to strengthen its existing collaboration with the UFS-NGS Unit, which initiated the application process to designate the UFS-NGS unit as a WHO CC, an initiative that has taken approximately 20 months to finalise through the different phases of the application and approvals for the designation,” explains Dr Nyaga.

The purpose of the WHO CC

The new WHO CC will upon request by the WHO, implement agreed work plans in a timely manner and to the highest possible standards of quality and must comply with the referred terms of reference and conditions. These include: 
• Conducting genome sequencing of pathogenic organisms causing VPD, including rotavirus strains collected as part of the routine VPD surveillance using NGS technology and analysis of the generated datasets using bioinformatics tools.

• Conducting molecular characterisation of specimens collected during outbreaks and public health emergencies as part of the support for monitoring, preparedness and response to VPD disease outbreaks in Africa.

• Provide technical guidance to WHO on strategies to improve laboratory molecular diagnostics, molecular typing and NGS of rotavirus diarrheal strains and other enteropathogens to detect novel and re-emerging strains. 

• Conduct validation of tools and new molecular diagnostics for detection and characterisation of unusual or rare VPD strains to guide studies and development of new vaccines for VPD.

• Organise capacity-building and training workshops on whole genome sequencing of priority VPD pathogenic organisms.

The impact of the WHO CC on the work of the UFS-NGS 

According to Dr Nyaga, the designation brings extra responsibilities to his work and to the activities of the UFS-NGS unit. “Such initiatives are very welcome to enhance the business aspects, research and academic activities of the UFS-NGS unit, as the benefits are quite holistic since the collaboration enhances co-ownership of data and offers opportunities to train postgraduate students and other scientists.

“It also expands the research infrastructure and most importantly contributes to policy for numerous African governments in important decisions such as vaccine implementation activities, from an informed point of view and managing public health needs that require rapid response like outbreaks that may lead to pandemics.” 
• The current WHO CC designations at South African Institutions of higher learning and research can be found at: 

News Archive

Horse-riding therapy improves self-confidence in children
2016-05-10


This group of Honours students in Psychology at the University of the Free State was honoured with the best postgraduate Service Learning award at the prize-giving function of the Faculty of the Humanities. From the left are Adriana de Vries, Hershel Meyerowitz, Simoné le Roux, Wijbren Nell, Melissa Taljaard, and Gerán Lordan. Photo: Marizanne Cloete.

Horse-riding therapy helps to improve self-confidence in children, and changes their perception of themselves. It puts them in a totally new environment where they can be free of any judgement.

According to Wijbren Nell, who achieved his Honours degree in Psychology at the University of the Free State (UFS), this is the ideal therapy when working with children with disabilities. He said it was amazing to see how they developed.

He was part of a group of Honours students in Psychology who received the best postgraduate Service Learning award in the Faculty of the Humanities for their community project. In 2015, this project by Wijbren, Hershel Meyerowitz, Gerán Lordan, Melissa Taljaard, Simoné le Roux, and Adriana de Vries, was part of their module Community and Social Psychology. They were honoured at the Faculty’s prize-giving function on 15 April 2016.

Purpose of project

“Our purpose with the project was to demonstrate to the children that they could still accomplish something, despite their disabilities,” Wijbren said. The students work on a weekly basis with learners from the foundation phase of the Lettie Fouché School in Bloemfontein. Marie Olivier’s Equistria Therapeutic Development Trust serves as the site for the community project. She has a long standing partnership with the UFS.

Horse-riding and therapy

According to Wijbren, the idea was to stimulate the psychomotor functioning of the children, as well as to promote their psychological well-being. He said research has shown that there is incredible therapeutic value in horse-riding. In this specific case, it has improved the children’s self-confidence, as they may have a poor self-image as a result of their disabilities.

“At the beginning of the year, there was a girl who didn’t even want to come close to a horse, let alone getting onto the horse. We kept on trying, and, once she was on the horse, we couldn’t get her down. This was the amazing thing about the project,” said Wijbren.

Award a surprise

Wijbren said the award was a honour and surprise to his group. He was full of praise for Dr Pravani Naidoo, a lecturer in Psychology at the UFS, who coordinates the therapeutic horse riding project. “She has a tremendous passion for this project, and challenged us to think on our feet. She is a real inspiration.”

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