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11 August 2021 | Story Dr Cindé Greyling | Photo Supplied
Leading a happy and productive workplace - Susan van Jaarsveld

Susan van Jaarsveld is the Senior Director: Human Resources at the University of the Free State. Since the HR department is the ‘go-to person’ for all employee-related matters, her duties involve managing activities such as recruitment and selection, employee relations, performance management, training and development, and talent management. “As the employees are the most important asset, we have to ensure a happy and productive workplace,” she explains. 

What is the best thing about your job?
You always move between what is good for the UFS and what is good for the employees, and you have to build that bridge and find a good balance. The best part is that you can really make a difference – for an employee or a team – by helping them to let their (hidden) talents come to life and helping them realise their dreams.

What is the best and worst decision you have ever made?
Two of the best decisions I ever made were to have my two amazing children. They have enriched my life and I cannot imagine a world without them in it. I made many bad decisions, but I choose not to dwell on those. In hindsight, many of these bad decisions taught me valuable life lessons and also led me to wonderful new opportunities.

What was/is the biggest challenge of your career?
The biggest challenge throughout my career was to balance my work and home life. This is certainly a challenge that many people, especially women, can relate to. It means constantly feeling guilty. When I was at work, I felt guilty that I’m missing out on important parts of my children’s lives, and I felt guilty when I was spending time with my family and not working. My children are both grown-up now and maintaining a balance between my home and work life has become easier.

What does the word woman mean to you?
Being a woman is complicated, multi-faceted, and often unfair. Womanhood is about strength, love, and compassion; a human being who can be powerful and assertive and kind at the same time.

Which woman inspires you, and why?
I am inspired by South African women, the single mothers who raise their children in difficult circumstances, the ones who make ends meet every day, the CEOs who manage big companies successfully, the ones who are battered and bruised by life and other people but still keep going, the health workers who are carrying us through this COVID-19 pandemic, the ones who stand up against injustice and say, ‘when you strike a woman, you strike a rock’.

What advice would you give to the 15-year-old you?
You are enough! Relax and enjoy life to the fullest.

What is the one self-care thing that you do? 
I exercise regularly, it helps me to stay healthy in body and mind.

What makes you a woman of quality, impact, and care?
I choose to be positive, fair, and caring in everything I do. It is a privilege to be part of the UFS, where I strive to continuously improve the institutional culture, together with a very supporting and competent team. Care (commitment, attraction, retention, excellence) is the acronym that best describes the vision of the HR team; we care and incorporate this into every initiative we undertake. 

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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