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11 February 2021 Photo UFS photo archive
The National Control Laboratory for Biological Products (NCL) Building.

There can be no compromise when it comes to the quality of medicines made available to the public.

The UFS-based National Control Laboratory for Biological Products (NCL) is a full member of the international WHO-National Control Laboratory Network for Biologicals and one of 12 laboratories worldwide contracted to perform vaccine testing for the World Health Organisation (WHO). The NCL is also the only vaccine-testing laboratory in the country that performs the final quality-control testing of all human vaccine batches marketed in South Africa on behalf of the South African Health Products Regulatory Authority (SAHPRA).

In its role as a vaccine-testing laboratory for the WHO, the NCL helps to ensure that the vaccines purchased through the WHO prequalification programme for international distribution to resource-limited countries, meet the high standards of quality, safety, and efficiency. 

International testing standards

The laboratory received the status of a pharmaceutical testing laboratory after the South African Accreditation System (SANAS) endorsed its quality-management systems as of a high standard according to the International Standards Organisation’s requirements.

With its international testing standards, the NCL must ensure that all its operations – from the way documents are compiled and stored, to the maintenance of equipment and infrastructure, as well as staff competency – are performed according to international guidelines.

The laboratory has all the quality systems in place to ensure high-quality test results. The certificate of Good Manufacturing Compliance received in 2019 indicates that laboratory testing is on the expected level for any pharmaceutical testing laboratory and manufacturer. This certification is very strict and means that the NCL complies with exceptionally strict standards for pharmaceutical labs anywhere in the world. The certification offers the South African Health Products Regulatory Authority, the WHO, and other national control laboratories around the world the confidence that the test results from the NCL can be trusted.

Licensed as pharmaceutical manufacturer

The laboratory is also licensed as a pharmaceutical manufacturer. Although the lab does not manufacture, it needs to comply with manufacturing standards. It is rare for a pharmaceutical testing laboratory (such as the NCL) outside of a manufacturing context to qualify for both certifications.

News Archive

Researcher works on finding practical solutions to plant diseases for farmers
2017-10-03

 Description: Lisa read more Tags: Plant disease, Lisa Ann Rothman, Department of Plant Sciences, 3 Minute Thesis,  

Lisa Ann Rothman, researcher in the Department of
Plant Sciences.
Photo: Supplied

 


Plant disease epidemics have wreaked havoc for many centuries. Notable examples are the devastating Great Famine in Ireland and the Witches of Salem. 

Plant diseases form, due to a reaction to suitable environments, when a susceptible host and viable disease causal organism are present. If the interactions between these three factors are monitored over space and time the outcome has the ability to form a “simplification of reality”. This is more formally known as a plant disease model. Lisa Ann Rothman, a researcher in the Department of Plant Sciences at the University of the Free State (UFS) participated in the Three Minute Thesis competition in which she presented on Using mathematical models to predict plant disease. 

Forecast models provide promise fighting plant diseases
The aim of Lisa’s study is to identify weather and other driving variables that interact with critical host growth stages and pathogens to favour disease incidence and severity, for future development of risk forecasting models. Lisa used the disease, sorghum grain mold, caused by colonisation of Fusarium graminearum, and concomitant mycotoxin production to illustrate the modelling process. 

She said: “Internationally, forecasting models for many plant diseases exist and are applied commercially for important agricultural crops. The application of these models in a South African context has been limited, but provides promise for effective disease intervention technologies.

Contributing to the betterment of society
“My BSc Agric (Plant Pathology) undergraduate degree was completed in combination with Agrometeorology, agricultural weather science. I knew that I wanted to combine my love for weather science with my primary interest, Plant Pathology. 
“My research is built on the statement of Lord Kelvin: ‘To measure is to know and if you cannot measure it, you cannot improve it’. Measuring the changes in plant disease epidemics allows for these models to be developed and ultimately provide practical solutions for our farmers. Plant disease prediction models have the potential ability to reduce the risk for famers, allowing the timing of fungicide applications to be optimised, thus protecting their yields and ultimately their livelihoods. I am continuing my studies in agriculture in the hope of contributing to the betterment of society.” 

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