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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

Department of English changed to empower students
2017-07-05

Description:Department of English  Tags: Department of English

Lecturers from the Department of English at the University of the Free State have been working
hard to create a robust learning environment for students through continuous assessment.
Photo: Sonia Small


A new curriculum, exciting third-year seminars, and a transition to continuous assessment. These are some of the changes made by the Department of English at the University of the Free State (UFS) over the past few years. The department, which also boasts four National Research Foundation (NRF) researchers, did this to tailor the curriculum towards the needs of its students and to foster a better culture of engagement.

According to Prof Helene Strauss, Head of the Department, the advantages of these changes are clear. “Staff have noted a significant improvement in both the basic writing and critical deliberation skills of our students, and in the responsibility they are taking for their own learning.” The new curriculum empowers students to take a position in relation to the knowledge they encounter in the classroom, thereby strengthening their own critical voice.

Taking continuous responsibility

One of the most significant changes for students was the fact that they have to take responsibility all the time. Prof Strauss says continuous assessment changed “last-minute cramming to near-daily, student-centred activities of reading, writing, and critical discovery.”

Because students have to prepare for lectures and reflect on materials, they are in a better position to internalise difficult debates and critical concepts. “Rather than telling students what to think, we help them develop flexible, critical tools to make sense of a changing world.”

Third-year seminars are another way of including forms of instruction that concentrate on the links between education and democracy, but still improve students’ ability to speak and write English accurately. Every semester, students can choose seminars from a range of topics such as ‘Witchcraft’ (Prof Margaret Raftery) and ‘The Art of Dying’ (Dr Mariza Brooks).

Research and associates around the world

Dr Marthinus Conradie, Dr Rodwell Makombe, Prof Irikidzayi Manase, and Prof Strauss are all NRF-rated researchers in the department.

The department also has affiliated research associates from countries including Zimbabwe, the USA, and Canada. Dr Kudzayi Ngara currently holds a competitive NRF grant for a project on Southern African urbanity, and Dr Philip Aghoghovwia recently received the prestigious African Humanities Programme Fellowship.

Under the guidance of Dr Ngara, the department has been able to roll out a new Honours programme on the Qwaqwa Campus. The campus now also offers students the opportunity to pursue MA and PhD studies.

Other highlights:
• Hosted the international Institute of the Association for Cultural Studies in 2015.
• Books published: Dr Susan Brokensha (with Burgert Senekal). Surfers van die Tsunami: Navorsing en Inligtingstegnologie binne die Geesteswetenskappe (SUN MeDIA, 2014); Prof Iri Manase. White Narratives: The depiction of post-2000 land invasions in Zimbabwe (UNISA Press, 2016); as well as co-edited volumes with Cambridge Scholars Publishing (Dr Oliver Nyambi) and Routledge (Prof Helene Strauss).
• Publications include three special journal issues (of ISI journals Critical Arts: South-North Cultural and Media Studies; Safundi: The Journal of South African and American Studies; Interventions: International Journal of Postcolonial Studies).

 



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