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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

Young language Einstein set for Europe
2017-07-10

Description: Young language Einstein set for Europe Tags: Recipient of UFS Senate medal receives Erasmus Mundus master’s bursary.  

Willem Carel Brink will be studying in France and Italy
for the next 
two years as part of his master’s
degree programme
Photo: Rulanzen Martin

German, French, English and even Latin are just a few of the languages known by Kovsies’ own language guru, Willem Carel Brink.

This arty junior lecturer and 2015 Senate and Dean’s medal recipient at the Department of Afrikaans and Dutch, German and French at the University of the Free State (UFS) received the Erasmus-Mundus bursary to conduct his master’s degree under the Erasmus Mundus Master en Cultures Littératures Européennes (CLE) title. He departs for Europe in September. “It is a structured interdisciplinary study which focuses on European literature, culture and other aspects,” Willem says. The subject for his thesis will be determined during the duration of the course.

Two-year course under Erasmus Mundus 
The Erasmus CLE master’s is a two-year course which is presented by five partner universities in France, Senegal, Italy and Greece. Students are expected to indicate at which universities they want to study but cannot spend both years at the same university. “France was my first choice, because I know the language – which was a prerequisite for selection,” said Willem. He is fluent in Afrikaans, English, German and French! 

“I will spend my second year in Bologna, Italy,” he said. It is therefore also expected that he does an Italian course during the first year to prepare him for the second year in Italy.

Future collaboration with UFS a prospect
Future collaborations between him and the language departments at the UFS are possible prospects for the future when he returns. “What makes this degree especially attractive to me is that it has value in terms of the local environment in the teaching of European languages and literature.” 

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