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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

International Bible scholars attend conference on Apocalyptic Literature and Mysticism
2017-09-18

Description: Bible Scholars Tags: Bible Scholars, UFS Faculty of Theology and Religion, Prof Francis Petersen 

Prof Francis Petersen, UFS Rector and Vice-Chancellor,
second from left, flanked by three
deans of theology: Prof Fanie Snyman (UFS),
Prof Jörg Frey (University of Zurich),
and Prof Gregory Sterling (Yale Divinity School).
Photo: Eugene Seegers


Apocalypticism and mysticism have become two key areas of research that have converged to form the heart of contemporary spirituality. It was with this in mind that leading local and international Bible scholars were invited to a collaborative international conference jointly hosted by the UFS Faculty of Theology and Religion and Yale Divinity School, with the theme Apocalyptic Literature and Mysticism—Investigating a Turn in Recent Apocalyptic Research.

It is perhaps unknown to many that a number of the most profound thinkers, both of Judeo-Christian tradition and other religions in general, were mystics. Their lives and writings speak of a longing for an intimate relationship with God, reflecting on universal existential questions such as understanding our human existence, our creation, and ultimately, the meaning of life.

Apocalypticism, on the other hand, focuses on texts and prophecies describing how an alternative, future world might replace our existing one, a process often cataclysmic in nature, thus, like the mystics, also reflecting on the deeper foundations of human existence and our possible demise.

Traditionally, both have been misunderstood and controversial, but more recent research has revealed their formative role in religious discourses, with many scholars finding growing commonalities between apocalyptic and mystical texts. Moreover, these commonalities help to establish a better understanding of Judeo-Christian traditions, as well as other religions in general.

This hugely successful UFS collaborative effort, as well as others of its kind, contribute to the growth of theology as a discipline, with a positive impact on the broader religious community, the church, and society as a whole in the common desire for a just, equitable, and humane world.

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