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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

Asive humbled by new responsibility
2017-09-27

Description: TEDxUFS   Tags: TEDxUFS

Asive Dlanjwa, President of the Student Representative
Council (SRC) on the Bloemfontein Campus, and Pura
Mgolombane, Dean of Student Affairs, during the
announcement of the 2017/2018 SRC.
Photo: Johan Roux

Nothing humbles him more than the fact that thousands of students had chosen to put their weight, hopes, and dreams behind him. The emotions Asive Dlanjwa felt when he was announced as the new President of the Student Representative Council (SRC) on the Bloemfontein Campus reveals something about his character.

He clearly understands the weight of the responsibility on his shoulders. Asive, who loves the church and cycling, says he felt a variety of emotions when he was announced as president on 31 August 2017 at the Thakaneng Bridge.

“It was an exciting feeling, but more than anything, it was such a humbling feeling; humbled not only by the excitement of the students when I was announced, but also by the fact that thousands of students had chosen to put their weight, hopes, and dreams behind me!”

Two main objectives

Asive and his SRC have two main objectives – to improve access to the university and advance the integration of our off-campus students into the greater campus community. The Bachelor of Commerce student from Umtata says there are several issues and initiatives his SRC will be tackling – all of them flowing from these objectives.

Including off-campus students

Asive says the SRC will seek to improve access to the university and its various offerings, and to also provide the necessary support to ensure their success. “Also within this objective would be to decisively deal with all forms of exclusion, from academic to financial to social and cultural exclusions perpetuated by systems and policies.”

With regards to off-campus students, he says university life previously revolved around residence life. He means the remains of that are still evident, to the detriment of the greater student community who are off-campus students.

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