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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

Newton Fellow at UFS focuses on land and labour
2017-10-28

Description: ' 000 Rory Pilossof Tags: Rory Pilossof 

Dr Rory Pilossof
Photo: Charl Devenish

Dr Rory Pilossof is a senior lecturer in economics at the University of the Free State (UFS), a Postdoctoral Fellow at the International Studies Group at UFS, and a Research Fellow at the University of Kent in the UK.

He became interested in his research field when he studied land reform and land issues in Zimbabwe for his PhD at the University of Sheffield. From there, his research interests have expanded to look at other issues connected to land, such as whiteness and labour.

Dr Pilossof's study field links up with the important issue of land reform in Southern Africa due to its past colonialism and post-colonial politics of land and land ownership. These intersect with a wide range of labour issues that are pressing in the region. He has a keen interest in elite transitions and changes in economic structure in Southern Africa since the 1960s.

Dr Pilossof was nominated to the South African Young Academy of Science in 2017, and received an NRF Y1 rating during 2017. He is also a member of the Amsterdam-based International Institute for Social History’s ‘Global Collaboratory on the History of Labour Relations’. He is a participant in the Leverhulme Trust-funded initiative ‘Comparative History of Political Engagement in Western and African Societies Programme’ at the University of Sheffield.

Dr Pilossof's primary research focuses on issues of land, labour and changing social and economic structures in Zimbabwe and South Africa. He is also interested in finding alternative ways of looking at change. To this end, he has studied various newspapers and periodicals in the region.

Currently, he spends most of his research time as part of a three-year British Academy-funded Advanced Newton Fellowship into labour relations and occupational structures. In future, he wants to expand his research in the labour field by looking at labour and migration in the region over the course of the 20th century.

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