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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.
The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com. 

News Archive

UFS experimental farm to be redesigned as a training facility
2004-10-25

Back fltr:
Dr Léan van der Westhuizen, Manager: UFS Sydenham Experimental Farm; Prof Herman van Schalkwyk, Dean: Faculty of Natural and Agricultural Sciences at the UFS and Councilor Thami Stander, Chairperson: Mangaung Municipal Portfolio for Agriculture and Rural Development

Front fltr:
Mr Hanz Nketu, Chairperson: Free State Legislative Committee on Agriculture and Mr Peter Frewen from the Free State Legislature

The Faculty of Natural and Agricultural Sciences of the University of the Free State will soon sign a tri-partite cooperation agreement with the National African Farmers Union (NAFU) and the Mangaung Local Municipality with the aim of providing training and mentorship to small-scale and emerging farmers, including those recently settled under the on-going land redistribution programme.

The agreement is part of the Faculty’s strategic plan to support the on-going reform process in the country, of which Black Economic Empowerment in Agriculture (Agri-BEE) is an important part. The Free State Provincial Department of Agriculture is also actively supporting this initiative.

Under the plan, the Faculty is redesigning its experimental farm, located about 12 kilometers south of Bloemfontein, as a training facility to build up skills in among others broiler and egg production, dairy farming, animal husbandry, piggery, sheep and goat production. The idea is to introduce a comprehensive package that empowers the small and emerging farmers and the local communities adjoining the farms through simultaneous investments in research, extension, and practical agricultural training.

Learnerships are also being drawn up to provide productive skills in order to contribute to addressing the national skills gap and enhancing opportunities for both self and wage employment.

The residents of the adjoining informal settlement known as Mangaung Phase II where unemployment is currently at extremely high levels are primary targets of this component of the project. The Faculty intends for this project to service the farming communities of the Free State Province and gradually spread to other Provinces in the country.

Having recognised this training programme as a potential instrument for achieving “a united and prosperous agricultural sector”, the Free State Legislature has shown considerable interest in the programme.

Following a preparatory visit to the farms by the Agriculture Committee of the Free State Legislature a request was made to the Faculty to host a larger visit by the Legislative Committees of the Free State, North West and Eastern Cape Provincial Legislatures on Monday 25 October 2004 and present details of the training programme.

The President of NAFU in the Free State Province, Mr Nox Nonkonyana, the Dean of the Faculty of Natural and Agricultural Sciences, Prof Herman van Schalkwyk, the Chair of the Mangaung Municipal Portfolio for Agriculture and Rural Development, Councilor Thami Stander, and the Chairperson of the Free State Legislative Committee on Agriculture, Mr M Nketu, will address the Legislators during the occasion.

Prof Herman van Schalkwyk

Dean: Faculty of Natural and Agricultural Sciences

University of the Free State, Bloemfontein

Media release
Issued by: Lacea Loader
Media Representative
Tel: (051) 401-2584
Cell: 083 645 2454
E-mail: loaderl.stg@mail.uovs.ac.za
25 Oktober 2004

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