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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.
The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com. 

News Archive

New Rector and Chancellor inaugurated at UFS
2003-02-07

NEW RECTOR AND CHANCELLOR INAUGURATED AT UFS

 Newly inaugurated Rector and Vice-Chancellor of the University of the Free State, Prof Frederick Fourie, has recommitted the university to the service of the broader community, through the pursuit of academic excellence and contributing to building a non-racial, democratic and just South Africa.

To make this a reality Prof Fourie proposed a social contract or accord between university constituencies and the community to chart the way forward to establishing a university that can meet the challenges of a developing democracy.

Prof Fourie was speaking at his inauguration ceremony on the Bloemfontein campus, where the former Ambassador to the United States, Dr Franklin Sonn, was also inaugurated as Chancellor of the UFS.

The twin inauguration ceremony – the first in the history of the UFS - was attended by former President Nelson Mandela, Education Minister, Kader Asmal, Free State Premier Winki Direko, and the executive mayor of Mangaung, Mr Pappie Mokoena, who all endorsed the appointments as evidence of the transformation of the UFS.

According to Prof Fourie, the greatest contribution that any university could make to social and economic development in South Africa was by being an excellent university that encouraged critical inquiry, scientific knowledge as well as community service.

“So whilst we cherish and foster the continuity of the university as part of the ageold international tradition of universities, this University embraces its particular role in this country now, embraces the changes in the form and scope of its role in this crucial period of our history. We are committed to making a real difference to the new nation,” he said.

His vision for the UFS was “to be a university of excellence, equity and innovation – a leader in research, teaching, community service, adult learning, transformation, non-racialism, non-sexism, multi-culturality and multilingualism – a contributor to our country and our continent’s growth and development – a truly South African university”.

Prof Fourie said the recent incorporation of the Qwaqwa campus of the University of the North into the University of the Free State, which is the first such incorporation to take place, would contribute to broadening access for poor communities to higher education. Introducing an innovation to the inauguration ceremony, Prof Fourie and the UFS staff pledged to their commitment to excellence and justice, quality and equity. Fourie is the 13th Rector of the University of the Free State, succeeding Prof. Stef Coetzee, and Dr Sonn is the 6th Chancellor, succeeding Ms Winkie Direko, Premier of the Free State.

In his inaugural address, Dr Sonn said the significance of today’s ceremony was that the UFS - as a former institution of the Afrikaner – had chosen to walk the path of justice and not merely survival. “This university has seemingly liberated itself. It is inclusively South African.

He said the academic community must play its role of vigilance and not indifference”. Referring to the stature of former president Mandela in international affairs, Dr Sonn said: “We must bring the weight ot science and critical analysis and interpretation to bear in support of Madiba and other moral giants.”
 

 

Inauguration Speech by Prof. Frederick C.v.N. Fourie  (PDF format)

Inauguration Speech by Dr Franklin A. Sonn (PDF format)

Statement by the Minister of Education, Professor Kader Asmal (PDF format)

Speech by Prof. Viljoen (PDF format)

Speech by Executive Mayor Mokoena - Mangaung Local Municipality (PDF format)

 

 

 

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