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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.
The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com. 

News Archive

UFS plans to improve undergraduate pass rate
2005-01-13

The University of the Free State (UFS) will introduce a new foundation programme this year 2005 in an effort to improve the academic performance of undergraduate students.

According to Mr Francois Marais, Head: Centre for Higher Education Studies and Development (CHESD) at the UFS, the programme will assist students by providing for the development of cognitive and critical thinking skills by means of the integration of appropriate thinking skills (such as creative thinking, decision-making, problem solving, reasoning, and how to learn), into the subject content of university courses.

“The foundation programme will benefit students from disadvantaged school backgrounds and, in future, those whose performance in proficiency tests points to the need for additional development in, for example, language proficiency, mathematical literacy, computer skills and life skills,” says Mr Marais.

Based on their level of achievement in the final Grade 12 examination (Senior Certificate), students will be referred to the foundation programme.

In order to improve students writing and reading abilities for higher education studies, foundation programme students will be offered academic language courses in English and Afrikaans.

Kovsie Counselling will render appropriate services, eg career guidance and support to these students.

The new foundation programme will be implemented in the faculties of Natural and Agricultural Sciences, Economic and Management Science, the Humanities and Law.

The duration for this programme differs from faculty to faculty. In the Faculty of Law it will take five years, while in the faculties of the Humanities, Natural and Agricultural Sciences, and Economic and Management Sciences it will take four years.

The national Department of Education will fund the foundation programme for three years. Funding for such programmes was made available to all higher education institutions in South Africa.

The welcoming function for all new first-year students and their parents will take place on Saturday 15 January 2005 at 11:00 in the Callie Human Centre on the main campus in Bloemfontein.

The registration of first-time entering first-year students who applied before 30 November 2004 to study at the Bloemfontein campus will take place from Monday 17 January 2005 to 21 January 2005 at the Callie Human Centre.

Senior undergraduate students (that is, students entering their second or later year of study) may register from 22 to 29 January 2005.

Postgraduate students, first time entering first year students and other students who applied for admission to the main campus after 30 November 2004 must register at the Callie Human from 31 January 2005 to 4 February 2005.

Due to the limitations placed by government on student numbers, the applications of students who applied late will be regarded as pending and will be processed as places become available.

    Media release
Issued by: Lacea Loader
Media Representative
Tel: (051) 401-2584
Cell: 083 645 2454
E-mail: loaderl.stg@mail.uovs.ac.za
13 January 2005

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