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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.
The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com. 

News Archive

UFS awarded tenders worth R22,5 million for Maths and Science teacher-training
2010-03-17

The Centre for Education Development (CED) at the University of the Free State (UFS) has received tenders worth about R22,5 million over the past two years from four provinces to train Mathematics and Science teachers from underperforming schools.

The CED has received tenders from the following provincial departments of education: Free State, Northern Cape, North West and Mpumalanga.

“The centre has a good reputation for the training of teachers in these disciplines and has been involved with the upgrading of Maths and Science teachers for at least 15 years,” said Prof. Daniella Coetzee, Director of the CED.

It is currently busy with the training of North West teachers after being awarded a R13,5 million tender by the Province as part of its quest to improve pass rates in Mathematics and Natural and Physical Sciences in underperforming schools.

“The tender is for the upgrading of the knowledge and methodology of teachers for Mathematics and Natural and Physical Science, as well as the upgrading of the knowledge of subject specialists in the North West Province,” said Prof. Coetzee.

For this project the centre trains 1 000 teachers and 90 subject specialists from underperforming schools over a period of three years.

The programme commenced in February this year with a baseline assessment of the teachers to determine knowledge and methodology gaps upon which to focus in the training.

“After the programme has been completed we will also do a post-assessment to see if there had been progress,” she said.

The training is offered only on Saturdays at Vryburg, Klerksdorp, Makapanstad, Brits and Zeerust and is presented by lecturers from the CED as well as selected and trained tutors from the North West province.

“We have successfully completed another Maths, Science and Technology project for the North West Department of Education. We have also completed similar projects for the Northern Cape and one for the Free State Department of Education,” she said.

These completed projects entailed formal qualifications (Advanced Certificate in Education) in Maths, Science and Technology and were worth in excess of R5 million.

The CED has just been recently awarded yet another tender in excess of R4 million over a period of two years by the Mpumalanga Department of Education.

Prof. Coetzee had the following to say about the CED being the preferred choice of these provincial Departments of Education: “It has to do with the fact that the CED has been performing well with the upgrading of teachers. It has proven itself as a leader in the in-service training of Maths and Science teachers in South Africa.”

Media Release
Issued by: Mangaliso Radebe
Assistant Director: Media Liaison
Tel: 051 401 2828
Cell: 078 460 3320
E-mail: radebemt@ufs.ac.za  
17 March 2010

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