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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.
The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com. 

News Archive

Department of Architecture builds next generation of architects
2010-03-22

 
With Prof. Jonathan Jansen, Rector and Vice-Chancellor of the UFS are René Malan en Sancha Olivier.


Since 1987 first-year architecture students have been building huts on campus annually as part of an introduction to architectural studies at the Department of Architecture at the University of the Free State (UFS).

According to Martie Bitzer, Senior Lecturer in the Department of Architecture, the students build these full-scale huts in groups of two, with responses to orientation, materials (grass, reads, earth construction – mud bricks), climate and community over a period of approximately three weeks.

On the day that the students completed their huts, Prof. Jonathan Jansen, Rector and Vice-Chancellor of the UFS, visited the small community of 27 huts in the veld behind the Rag Farm. Here he was taken on a walk amongst the huts. He also addressed staff and students of the Department of Architecture

“I can smell excellence and goodness,” was some of Prof. Jansen’s remarks as he walked amongst the huts.

“Top students come to our Department of Architecture. Quality attracts quality. The recent achievements of this department are proof of this,” he said.

One of Kovsies final-year students, Wim Steenkamp, was named National Corobrik Architecture Student of the Year 2008. This was the second time in the past three years that a student from the UFS Department of Architecture has won this prestigious competition. The department also received unconditional accreditation from the South African Council for the Architecture Profession (SACAP) for all three courses offered, and over the past few years its students have won the Tripod Photography Competition, the National Cement and Concrete Institute Competition for honours students, and the Carl and Emily Fuchs Foundation Student Prestigious Prize.

This once again confirms the prestige the department enjoys in the field of architecture in South Africa. It is also proof of the quality of staff and the programmes offered at the department.
 

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