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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

Honorary Professor delivers inaugural lecture in the Faculty of Theology
2010-10-27

Prof. Peter Lampe.

Prof. Peter Lampe recently delivered his inaugural lecture as an Honorary Professor in the Department of New Testament in the Faculty of Theology of the University of the Free State (UFS).

The title of Prof. Lampe’s inaugural lecture was Theology and rhetorics: how do "res" and "verba" relate to each other, in which he addressed the fundamental question of the role and importance of words and the issue/content in theology. Can content simply be conveyed in any manner? Also in theology, Martin Luther observed that some theologians’ works contain words (verba) and those of others the content (res). In his inaugural lecture, Prof. Lampe pointed out that our knowledge of God/reality specifically has to be construed through the use of words. Words and terminology therefore have to be selected with circumspection. Res and verba stand in close relation to each other.

Prof. Lampe declared that in the post-modern world, a “competition” exists for the best constructed worldview and theologians could make a significant contribution to the construction of a better reality through better judgement of the words they use. 

Prof. Lampe, currently the Chair of New Testament Theology at the University of Heidelberg in Germany, has a rich and varied history in the field of theology. Having attained degrees in theology, philosophy and archaeology in Gottingen, Rome and Berne, Prof. Lampe has enjoyed an illustrious professional career. After receiving his Ph.D. at the University of Berne and teaching New Testament Studies there, Prof. Lampe held the Chairs of New Testament Studies in Virginia (USA) and History and Archaeology of Early Christians in Kiel (Germany), before being appointed to the post he currently holds.

In 2003 he was awarded the German Ecumenical Preaching Award and in Turkey he was the leader of an expedition that discovered the long-lost Montanist headquarters of Pepouza and Tymion.

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