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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

Cultivating excellence and success through academics
2011-10-07

 

Unlocking potential. At the Golden Key South African Summit 2011 were, from the left: Dr Derek Swemmer, Registrar (UFS); Prof. Driekie Hay, Vice-Rector: Academic; Mr Ryk Neethling and Ms Charlene Gunter, Director: Golden Key International Honour Society, South Africa.
Photo: Phelekwa Mpono

More than 130 delegates are gathering for the Golden Key, South African Summit at the Bloemfontein Campus of the University of the Free State (UFS). Golden Key International Honour Society recognises academic excellence and uses knowledge to transform lives. It has 400 chapters in eight countries. Of South Africa’s 12 chapters, 11 were present at the summit.

Prof. Driekie Hay, Vice-Rector: Academic at the UFS, welcomed delegates from the respective chapters. She commended them for their perseverance and dedication to excel. “Your academic aspirations and commitment contribute to cultivating a culture of excellence. It will provide a better future for every South African citizen,” she said. Prof. Hay challenged delegates also to “act” by turning their knowledge into actions to advance not only themselves but also society. She also urged them to “discover” everything about themselves, their chosen disciplines, allies and oppositions. “Mostly, you must internalise the spirit of lifelong learning,” she said.

Mr Ryk Neethling, Olympic gold medallist and businessman, was the first keynote speaker. He took everyone through the steps that ultimately led to the moment of victory for him and his team. “We found a way to compete with heart and determination in the 2004 Olympic Games. We were prepared and we took everyone by surprise. “To achieve what one has set one’s mind to, we must dream big,” he said. “Play your part in the team and be confident. Remember that you are victors and not victims,” he urged. He further emphasised the importance of making one’s own luck and, most of all, never to give up.

Another speaker for the summit includes Ms Peggy-Sue Khumalo, former Miss South Africa. Dr Derek Swemmer, Registrar (UFS) will present a workshop on Strategic Action Planning.

This event is the first external lecture that is presented in the Metro’s found in the new Health Sciences Building on the Bloemfontein Campus of the UFS.
 

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