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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.
The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com. 

News Archive

Intervarsity postponed to 2013
2012-03-08

The annual Intervarsity between the Universities of the Free State and North-West (NWU), which traditionally takes place in the third term, has been postponed to 2013.

The Intervarsity between the UFS and NWU is an illustrious event that has already reached the special milestone of celebrating a 70-year Intervarsity tradition. The UFS/NWU Intervarsity is also known as one of the most reckoned events on the local and national sports and student calendars, and it is widely supported.
 
Representatives from both universities could for a variety of reasons not decide on a date which suited both universities.
 
The respective Intervarsity committees and senior managers of both universities have also taken the interests of the respective university communities and alumni of the institutions into account and have decided to postpone the 70th-year celebration of Intervarsity by a year in order to be able to celebrate the milestone properly.
 
The UFS would have received the NWU in Bloemfontein this year and will therefore host the 70-year celebrations of the event next year as well.
 
Mr Rudi Buys, Dean: Student Affairs at the UFS has expressed his gratitude for the fact that both universities are committed to a special celebration of the Intervarsity tradition in 2013.
 
“The celebration of the 70th Intervarsity between the two institutions will be an important milestone to commemorate decades of friendship, collaboration and healthy competition. Therefore we welcome this opportunity to plan a bigger and better programme for 2013,” he said.
 
The UFS-NWU 70-YEAR Intervarsity firstly aims to establish the programme as a proud example for both universities, where students and staff can pit their strengths against one another in a healthy manner.
 
The aim is to extend Intervarsity to various sections of the respective university communities to enable more students to participate. For instance, more sports codes will be added to the traditional competition on the rugby, soccer, netball and hockey fields, whilst various events focusing on arts and culture, i.e. choral singing and debating competitions, as well as dialogue between student leaders, will take place as part of the programme. All campuses of the two universities will participate in the programmes.
 
Students are even investigating the possibility of electronic competitions such as on-line games as part of the Intervarsity
 
During the Intervarsity last year, several new possibilities were already tested to ensure that the 70th anniversary would be a huge success.
 
The Central Intervarsity Committee of the UFS has decided to replace the Intervarsity 2012 programme with an INTRA-varsity programme between its respective campuses. For this occasion, various sports, arts and culture, and leadership events between the Bloemfontein and Qwaqwa Campuses are planned, and the Central University of Technology might be invited as well to participate as guests in some programmes.

Media Release
8 March 2012
Issued by: Lacea Loader
Director: Strategic Communication
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: news@ufs.ac.za


 

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