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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.
The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com. 

News Archive

Excellent facilities, pleasant weather and hospitality attract international teams
2012-03-14

 

Germany and South Africa played friendly practice matches at the UFS during their training camps.
Photo: Johan Roux
14 March 2012

Three international hockey teams have used the practice facilities of the university since the beginning of the year to prepare for the Olympic Games in August this year. The German and South African hockey teams have practiced here on four previous occasions.

Due to the cold weather in Europe, Austria also held its hockey training camp at the university this year. In addition, four of Austria’s triathlon athletes used the cross country track and swimming pool on the Bloemfontein Campus to prepare for the Olympic Games.

Germany’s national hockey team practised at the university from 3 to 12 March 2012. South Africa made use of the facilities from 5 to 10 March and Austria’s national team has been practicing in Bloemfontein since 24 February. From 3 to 10 March, a club team from Austria also made use of the university’s facilities, including the astros, the swimming pool, the athletics track and the Biokinetics Centre. SV Arminem also played two matches against the men’s hockey team from Kovsies. The first match end 2-2. With the second match Kovsies won 4-1.

Other international hockey teams who have made use of the astros over the past six years include Russia, Argentina, Belgium, China, Azerbaidjan and the Netherlands.

Staff ensured that everything ran like clockwork during the different training camps. Ms Annemarie Ludick and Mr Frans van der Watt, under the guidance of Mr Mickey Gordon, Head: Institutional Promotion, Fundraising, Marketing and Sport, were responsible for the logistical arrangements and finances. Mr Johan Gerber saw to the maintenance of the astros. The university boasts some of the best equipped astros in the world. “Germany, for example, did not bring along any exercise balls, cones, or beds (for use by physiotherapists) because the astros are fully equipped,” said Ms Ludick.

The fact that international teams such as Germany (ranked second in the world), South Africa and Austria made use of the university’s facilities is significant. “The university’s first team got for example the opportunity to play practice games against these players. The training camps also contributed to the economy of Bloemfontein,” said Ms Ludick.

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