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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

‘Leadership is formed through ethical behaviour’
2012-08-20

Mr Edward Kieswetter
20 August 2012

“Being ethical is not about what we can do, it is about what we ought to do.” This is according to Mr Edward Kieswetter, Group Executive of Alexander Forbes Limited. During his lecture to MBA students in the Business School, Mr Kieswetter allowed the audience to engage in a discussion about ethics and leadership in the business world. Mr Kieswetter is also Vice-Chairperson of the UFS Council.

Part of the lecture was discussing South Africa as a country that was not born in ethics. Mr Kieswetter commented that although context was is very important in making decisions, South African people tended to, for example, and “feed on corruption, instead of acting actively against it”. Questions about South Africa’s ethical foundation were raised. Mr Kieswetter explained that one of the greatest challenges with the South Africans was to help them understand that a person always had a choice. “If you have to compromise on your own values, you are not doing anybody justice.”

Ethics can promote common and social goals if they are not determined by what people feel and strive to reach beyond the barriers that religious beliefs put up. He shared of his life’s most valuable lessons learned about people in leadership positions. “A great leader has incredible self-awareness and displays a huge amount of humility.” He said that in life it was not about being perfect; it was rather about being authentic, even in challenging times where the outcome might affect the current situation negatively. “My greatest successes came from lessons I learned in making mistakes and growing from them.

“If you have nothing to die for, then what is there to live for?” Mr Kieswetter said when asked whether he would compromise his financial position if he did not agree with the ethics of the company he worked for. “By constantly complaining instead of progressing, we are giving up our power to change, and that is a scary thing for South Africa as a developing country.” 
 

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