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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.
The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com. 

News Archive

New facility helps with better clinical training
2012-09-06

 
The new Authentic Learning Space at the School of Nursing allows students to practice very important skills in their state-of-the-art patient simulation rooms.
Photo: Supplied.
4 September 2012

When you visit the School of Nursing at the Bloemfontein Campus of the University of the Free State (UFS), you will be alarmed by all the casualties and patients being treated here daily.

There are patients with serious penetration wounds, as well as open and laceration wounds which could be fatal if not attended to urgently.

In one ward a child is being treated for breathing difficulties and in the emergency ward a patient who suffered a heart attack has just been rushed in.

At the end of the session students pack up their textbooks and the ‘patients’ are re-programmed and prepared for the next group of nursing students to practice their clinical skills.

The School of Nursing recently had the official opening for their Authentic Learning Space where they showcased their state-of-the-art patient simulation rooms.

In each of the many examining rooms as well as in the high-care rooms there are simulation mannequins that can be programmed for certain medical conditions or for medical emergencies.

Speaking at the opening of the Authentic Learning Space, Prof. Driekie Hay, Vice-Rector: Academic, said universities are often accused of not preparing students adequately for their careers.

“We know students learn better by interaction. With access to authentic learning spaces, students are able to gain a deeper sense of a discipline and they can begin to grasp the unwritten knowledge of practice that is often used on a daily basis.”

 

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