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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

Inspiration from an Olympic Champion for Spring graduandi
2012-09-20

Photo: Hannes Pieterse
20 September 2012

The guest list for the Spring Graduation ceremony of the University of the Free State included an Olympic gold medallist, a former Miss South Africa finalist and the Prime Minister of a neigbouring country.

The new graduates could draw inspiration from Olympic swimming champion Chad le Clos, who was the guest speaker at the event. Also attending was the Prime Minister of Lesotho, the Honourable Thomas Thabane, who came to watch his grandson graduating from Kovsies. Sharing a stage with Le Clos was Rolene Strauss, a medical student, who was among the top five contestants at last year’s Miss South Africa competition.

Le Clos, who became a national hero in July when he won a gold medal in the 200 m butterfly at the Olympic Games by beating American swimming legend Michael Phelps, told new graduates to strive for the impossible. Giving them insight into his remarkable achievement, Le Clos told them nobody had expected him to beat Michael Phelps. “Even I thought it was impossible to achieve. Always have a goal and work towards it,” he told them and said his ambition was to build up swimming in South Africa. Le Clos said he hoped that by 2016 there would be more swimmers making South Africa proud.

Prof. Jonathan Jansen, Vice-Chancellor and Rector of the university, delivered an Olympic-inspired message. Quoting the motto of the modern Olympic Games, ‘faster, higher and stronger’, Prof. Jansen told the new graduates that they had to be better than those who came before them. “I expect my students in a troubled country to learn how to be different, faster, higher and stronger. Faster means efficiency; it means to be responsive to those in need."

Drawing lessons for the country from Le Clos' victory, Dr Khotso Mokhele, Chancellor of the University, told the graduates to choose optimism. Referring to the Marikana mine tragedy, Dr Mokhele said the country was far from taking the last stroke. “Even if it looks as if the curtain is down; remember that final stroke of Chad le Clos and how the great Michael Phelps was defeated.”
 

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